Sialic acid-binding Ig-like lectin 15 (SIGLEC15)
Homo sapiens — UniProt Q6ZMC9
Data last refreshed: (UniProt release unknown)
Key facts
Sialic acid-binding Ig-like lectin 15 (SIGLEC15) is a protein from Homo sapiens identified by UniProt accession Q6ZMC9, 328 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q6ZMC9; gene symbol SIGLEC15.
- Organism: Homo sapiens.
- Length: 328 amino acids.
- Top disease associations (Open Targets): esophageal carcinoma, gastric carcinoma and urinary bladder carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sialic acid-binding Ig-like lectin 15 |
|---|---|
| UniProt accession | Q6ZMC9 |
| Gene | SIGLEC15 |
| Organism | Homo sapiens |
| Length | 328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- esophageal carcinoma · score 0.14
- gastric carcinoma · score 0.14
- urinary bladder carcinoma · score 0.12
- neoplasm · score 0.12
- cancer · score 0.11
- hepatocellular carcinoma · score 0.10
- lung adenocarcinoma · score 0.09
- bladder transitional cell carcinoma · score 0.08
- non-small cell lung carcinoma · score 0.08
- osteosarcoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMC9-F1 | alphafold | PREDICTED | 78.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMC9.
Amino-acid sequence (328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIGLEC15?
The strongest Open Targets associations for SIGLEC15 are esophageal carcinoma, gastric carcinoma, urinary bladder carcinoma, neoplasm and cancer.
How long is the SIGLEC15 protein?
The Homo sapiens SIGLEC15 protein (UniProt Q6ZMC9) is 328 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMC9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMC9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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