Ceramide synthase 6 (CERS6)
Homo sapiens — UniProt Q6ZMG9
Data last refreshed: (UniProt release unknown)
Key facts
Ceramide synthase 6 (CERS6) is a protein from Homo sapiens identified by UniProt accession Q6ZMG9, 384 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.
- UniProt accession: Q6ZMG9; gene symbol CERS6.
- Organism: Homo sapiens.
- Length: 384 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, FEV/FVC ratio and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ceramide synthase 6 |
|---|---|
| UniProt accession | Q6ZMG9 |
| Gene | CERS6 |
| Organism | Homo sapiens |
| Length | 384 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (114)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.50
- FEV/FVC ratio · score 0.41
- forced expiratory volume · score 0.41
- mean corpuscular hemoglobin concentration · score 0.41
- neurodegenerative disease · score 0.35
- HbA1c measurement · score 0.32
- type 2 diabetes mellitus · score 0.31
- bipolar disorder · score 0.30
- mean corpuscular hemoglobin · score 0.30
- peak expiratory flow · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMG9-F1 | alphafold | PREDICTED | 86.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMG9.
Amino-acid sequence (384 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CERS6?
The strongest Open Targets associations for CERS6 are Red cell distribution width, FEV/FVC ratio, forced expiratory volume, mean corpuscular hemoglobin concentration and neurodegenerative disease.
How long is the CERS6 protein?
The Homo sapiens CERS6 protein (UniProt Q6ZMG9) is 384 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMG9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMG9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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