Protein phosphatase 1 regulatory subunit 21 (PPP1R21)
Homo sapiens — UniProt Q6ZMI0
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1 regulatory subunit 21 (PPP1R21) is a protein from Homo sapiens identified by UniProt accession Q6ZMI0, 780 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q6ZMI0; gene symbol PPP1R21.
- Organism: Homo sapiens.
- Length: 780 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, genetic disorder and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 21 |
|---|---|
| UniProt accession | Q6ZMI0 |
| Gene | PPP1R21 |
| Organism | Homo sapiens |
| Length | 780 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- genetic disorder · score 0.41
- Neurodevelopmental disorder · score 0.37
- Hepatosplenomegaly · score 0.37
- Abnormality of the respiratory system · score 0.37
- mean corpuscular hemoglobin concentration · score 0.32
- erythrocyte count · score 0.31
- body height · score 0.30
- red blood cell density measurement · score 0.28
- self reported educational attainment · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMI0-F1 | alphafold | PREDICTED | 83.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMI0.
Amino-acid sequence (780 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP1R21?
The strongest Open Targets associations for PPP1R21 are neurodegenerative disease, genetic disorder, Neurodevelopmental disorder, Hepatosplenomegaly and Abnormality of the respiratory system.
How long is the PPP1R21 protein?
The Homo sapiens PPP1R21 protein (UniProt Q6ZMI0) is 780 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMI0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMI0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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