Interleukin-34 (IL34)

About Interleukin-34

Interleukin-34 (IL34) is a protein from Homo sapiens identified by UniProt accession Q6ZMJ4, 242 residues long. MolForge cross-references it against 0 known binders and 309 disease associations.

Target properties

Protein name	Interleukin-34
UniProt accession	Q6ZMJ4
Gene	IL34
Organism	Homo sapiens
Length	242 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (309)

Diseases linked to this target (Open Targets).

neuroimaging measurement · score 0.41
cortical surface area measurement · score 0.38
brain measurement · score 0.38
neurodegenerative disease · score 0.36
cortical thickness · score 0.35
brain volume measurement · score 0.34
intraocular pressure measurement · score 0.29
type 2 diabetes mellitus · score 0.27
low density lipoprotein cholesterol measurement · score 0.27
apolipoprotein B measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZMJ4-F1	alphafold	PREDICTED	79.69	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMJ4.

Amino-acid sequence (242 residues)

MPRGFTWLRY LGIFLGVALG NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards