Transmembrane protease serine 11A (TMPRSS11A)
Homo sapiens — UniProt Q6ZMR5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protease serine 11A (TMPRSS11A) is a protein from Homo sapiens identified by UniProt accession Q6ZMR5, 418 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q6ZMR5; gene symbol TMPRSS11A.
- Organism: Homo sapiens.
- Length: 418 amino acids.
- Top disease associations (Open Targets): esophageal squamous cell carcinoma, non-small cell lung carcinoma and Wilson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protease serine 11A |
|---|---|
| UniProt accession | Q6ZMR5 |
| Gene | TMPRSS11A |
| Organism | Homo sapiens |
| Length | 418 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- esophageal squamous cell carcinoma · score 0.06
- non-small cell lung carcinoma · score 0.06
- Wilson disease · score 0.06
- psoriasis · score 0.05
- esophageal adenocarcinoma · score 0.04
- cancer · score 0.03
- influenza A (H1N1) · score 0.02
- oral squamous cell carcinoma · score 0.02
- C-X-C motif chemokine 10 measurement · score 0.02
- Duane retraction syndrome · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMR5-F1 | alphafold | PREDICTED | 87.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMR5.
Amino-acid sequence (418 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMPRSS11A?
The strongest Open Targets associations for TMPRSS11A are esophageal squamous cell carcinoma, non-small cell lung carcinoma, Wilson disease, psoriasis and esophageal adenocarcinoma.
How long is the TMPRSS11A protein?
The Homo sapiens TMPRSS11A protein (UniProt Q6ZMR5) is 418 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMR5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMR5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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