SH3 and cysteine-rich domain-containing protein 2 (STAC2)
Homo sapiens — UniProt Q6ZMT1
Data last refreshed: (UniProt release unknown)
Key facts
SH3 and cysteine-rich domain-containing protein 2 (STAC2) is a protein from Homo sapiens identified by UniProt accession Q6ZMT1, 411 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q6ZMT1; gene symbol STAC2.
- Organism: Homo sapiens.
- Length: 411 amino acids.
- Top disease associations (Open Targets): Rare pervasive developmental disorder, creatinine measurement and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH3 and cysteine-rich domain-containing protein 2 |
|---|---|
| UniProt accession | Q6ZMT1 |
| Gene | STAC2 |
| Organism | Homo sapiens |
| Length | 411 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- Rare pervasive developmental disorder · score 0.27
- creatinine measurement · score 0.19
- glomerular filtration rate · score 0.17
- neutrophil count · score 0.13
- wellbeing measurement · score 0.13
- alcohol consumption measurement · score 0.13
- pathological myopia · score 0.11
- Myopia · score 0.11
- Red cell distribution width · score 0.06
- IGF-1 measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMT1-F1 | alphafold | PREDICTED | 66.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMT1.
Amino-acid sequence (411 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with STAC2?
The strongest Open Targets associations for STAC2 are Rare pervasive developmental disorder, creatinine measurement, glomerular filtration rate, neutrophil count and wellbeing measurement.
How long is the STAC2 protein?
The Homo sapiens STAC2 protein (UniProt Q6ZMT1) is 411 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMT1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMT1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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