Death domain-containing protein 1 (DTHD1)
Homo sapiens — UniProt Q6ZMT9
Data last refreshed: (UniProt release unknown)
Key facts
Death domain-containing protein 1 (DTHD1) is a protein from Homo sapiens identified by UniProt accession Q6ZMT9, 781 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q6ZMT9; gene symbol DTHD1.
- Organism: Homo sapiens.
- Length: 781 amino acids.
- Top disease associations (Open Targets): neutrophil count, leukocyte count and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Death domain-containing protein 1 |
|---|---|
| UniProt accession | Q6ZMT9 |
| Gene | DTHD1 |
| Organism | Homo sapiens |
| Length | 781 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.49
- leukocyte count · score 0.48
- monocyte count · score 0.45
- myeloid white cell count · score 0.41
- FEV/FVC ratio · score 0.34
- basophil percentage of leukocytes · score 0.33
- brain aneurysm · score 0.31
- anxiety · score 0.27
- metabolite measurement · score 0.22
- Retinal dystrophy · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMT9-F1 | alphafold | PREDICTED | 69.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMT9.
Amino-acid sequence (781 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DTHD1?
The strongest Open Targets associations for DTHD1 are neutrophil count, leukocyte count, monocyte count, myeloid white cell count and FEV/FVC ratio.
How long is the DTHD1 protein?
The Homo sapiens DTHD1 protein (UniProt Q6ZMT9) is 781 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMT9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMT9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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