Echinoderm microtubule-associated protein-like 6 (EML6)

Homo sapiens — UniProt Q6ZMW3

Gene: EML6Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Echinoderm microtubule-associated protein-like 6 (EML6) is a protein from Homo sapiens identified by UniProt accession Q6ZMW3, 1958 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

UniProt accession: Q6ZMW3; gene symbol EML6.
Organism: Homo sapiens.
Length: 1958 amino acids.
Top disease associations (Open Targets): neutrophil count, heel bone mineral density and mean arterial pressure.
3D structure: AlphaFold model available.

Target properties

Protein name	Echinoderm microtubule-associated protein-like 6
UniProt accession	Q6ZMW3
Gene	EML6
Organism	Homo sapiens
Length	1958 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.40
heel bone mineral density · score 0.37
mean arterial pressure · score 0.36
leukocyte count · score 0.36
mean platelet volume · score 0.34
hypertension · score 0.33
sum of basophil and neutrophil counts · score 0.32
episodic memory · score 0.32
serum hepcidin measurement · score 0.32
reticulocyte measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZMW3-F1	alphafold	PREDICTED	87.23	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMW3.

Amino-acid sequence (1958 residues)

MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHSQKFFLGH NDDIISLALH PDKTLVATGQ VGKEPYICIW DSYNVQTVSL LKDVHTHGVA CLAFDSDGQR LASVGLDAKN TVCIWDWRKG KLLASATGHS DRIFDISWDP YQPNRVVSCG VKHIKFWTLC GNALTAKRGI FGKTGDLQTI LCLACAKEDI TYSGALNGDI YVWKGLNLVR TIQGAHSAGI FSMYACEEGF ATGGRDGCIR LWDTDFKPIT KIDLRETEQG YKGLSIRSVC WKADRLLAGT QDSEIFEVIV RERDKPMLIL QGHCEGELWA LALHPKKPLA VTGSDDRSVR LWSLADHALI ARCNMEEAVR SVAFSPDGSQ LALGMKDGSF IVLRVRDMTE VVHIKDRKEV IHEMKFSPDG SYLAVGSNDG PVDVYAVAQR YKKIGECSKS LSFITHIDWS LDSKYLQTND GAGERLFYRM PSGKPLTSKE EIKGIPWASW TCVKGPEVSG IWPKYTEVTD INSVDANYNS SVLVSGDDFG LVKLFKFPCL KRGAKFRKYV GHSAHVTNVR WSHDFQWVLS TGGADHSVFQ WRFIPEGVSN GMLETAPQEG GADSYSEESD SDLSDVPELD SDIEQEAQIN YDRQVYKEDL PQLKQQSKEK NHAVPFLKRE KAPEDSLKLQ FIHGYRGYDC RNNLFYTQAG EVVYHIAAVA VVYNRQQHSQ RLYLGHDDDI LSLTIHPVKD YVATGQVGRD AAIHVWDTQT LKCLSLLKGQ HQRGVCALDF SADGKCLVSV GLDDFHSIVF WDWKKGEKIA TTRGHKDKIF VVKCNPHHVD KLVTVGIKHI KFWQQAGGGF TSKRGTFGSV GKLETMMCVS YGRMEDLVFS GAATGDIFIW KDILLLKTVK AHDGPVFAMY ALDKGFVTGG KDGIVELWDD MFERCLKTYA IKRSALSTSS KGLLLEDNPS IRAITLGHGH ILVGTKNGEI LEIDKSGPMT LLVQGHMEGE VWGLAAHPLL PICATVSDDK TLRIWELSAQ HRMLAVRKLK KGGRCCAFSP DGKALAVGLN DGSFLVVNAD TVEDMVSFHH RKEMISDIKF SKDTGKYLAV ASHDNFVDIY NVLTSKRVGI CKGASSYITH IDWDSRGKLL QVNSGAREQL FFEAPRGKRH IIRPSEIEKI EWDTWTCVLG PTCEGIWPAH SDITDVNAAS LTKDCSLLAT GDDFGFVKLF SYPVKGQHAR FKKYVGHSAH VTNVRWLHND SVLLTVGGAD TALMIWTREF VGTQESKLVD SEESDTDVEE DGGYDSDVAR EKAIDYTTKI YAVSIREMEG TKPHQQLKEV SVEERPPVSR AAPQPEKLQK NNITKKKKLV EELALDHVFG YRGFDCRNNL HYLNDGADII FHTAAAGIVQ NLSTGSQSFY LEHTDDILCL TVNQHPKYRN VVATSQIGTT PSIHIWDAMT KHTLSMLRCF HSKGVNYINF SATGKLLVSV GVDPEHTITV WRWQEGAKVA SRGGHLERIF VVEFRPDSDT QFVSVGVKHM KFWTLAGSAL LYKKGVIGSL GAAKMQTMLS VAFGANNLTF TGAINGDVYV WKDHFLIRLV AKAHTGPVFT MYTTLRDGLI VTGGKERPTK EGGAVKLWDQ EMKRCRAFQL ETGQLVECVR SVCRGKGKIL VGTKDGEIIE VGEKNAASNI LIDGHMEGEI WGLATHPSKD LFISASNDGT ARIWDLADKK LLNKVSLGHA ARCAAYSPDG EMVAIGMKNG EFVILLVNSL KVWGKKRDRK SAIQDIRISP DNRFLAVGSS EHTVDFYDLT QGTNLNRIGY CKDIPSFVIQ MDFSADGKYI QVSTGAYKRQ VHEVPLGKQV TEAVVIEKIT WASWTSVLGD EVIGIWPRNA DKADVNCACV THAGLNIVTG DDFGLVKLFD FPCTEKFAKH KRYFGHSAHV TNIRFSYDDK YVVSTGGDDC SVFVWRCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with EML6?

The strongest Open Targets associations for EML6 are neutrophil count, heel bone mineral density, mean arterial pressure, leukocyte count and mean platelet volume.

How long is the EML6 protein?

The Homo sapiens EML6 protein (UniProt Q6ZMW3) is 1958 amino acids long.

Browse: Targets: E · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6ZMW3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6ZMW3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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