E3 ubiquitin-protein ligase RNF19B (RNF19B)
Homo sapiens — UniProt Q6ZMZ0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF19B (RNF19B) is a protein from Homo sapiens identified by UniProt accession Q6ZMZ0, 732 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.
- UniProt accession: Q6ZMZ0; gene symbol RNF19B.
- Organism: Homo sapiens.
- Length: 732 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, serum albumin measurement and clear cell renal carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF19B |
|---|---|
| UniProt accession | Q6ZMZ0 |
| Gene | RNF19B |
| Organism | Homo sapiens |
| Length | 732 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- serum albumin measurement · score 0.24
- clear cell renal carcinoma · score 0.18
- mosaic loss of chromosome Y measurement · score 0.16
- body mass index · score 0.11
- neoplasm · score 0.09
- hepatocellular carcinoma · score 0.08
- infection · score 0.07
- infect · score 0.07
- granular corneal dystrophy type I · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMZ0-F1 | alphafold | PREDICTED | 57.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMZ0.
Amino-acid sequence (732 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF19B?
The strongest Open Targets associations for RNF19B are neurodegenerative disease, serum albumin measurement, clear cell renal carcinoma, mosaic loss of chromosome Y measurement and body mass index.
How long is the RNF19B protein?
The Homo sapiens RNF19B protein (UniProt Q6ZMZ0) is 732 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMZ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMZ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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