Nesprin-3 (SYNE3)
Homo sapiens — UniProt Q6ZMZ3
Data last refreshed: (UniProt release unknown)
Key facts
Nesprin-3 (SYNE3) is a protein from Homo sapiens identified by UniProt accession Q6ZMZ3, 975 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.
- UniProt accession: Q6ZMZ3; gene symbol SYNE3.
- Organism: Homo sapiens.
- Length: 975 amino acids.
- Top disease associations (Open Targets): neuroticism measurement, PR interval and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nesprin-3 |
|---|---|
| UniProt accession | Q6ZMZ3 |
| Gene | SYNE3 |
| Organism | Homo sapiens |
| Length | 975 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (82)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.40
- PR interval · score 0.36
- protein measurement · score 0.34
- diffuse plaque measurement · score 0.12
- PHF-tau measurement · score 0.11
- Herpes simplex infection · score 0.10
- cancer · score 0.09
- neoplasm · score 0.09
- Waldenstrom macroglobulinemia · score 0.09
- dimethylglycine measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZMZ3-F1 | alphafold | PREDICTED | 80.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZMZ3.
Amino-acid sequence (975 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SYNE3?
The strongest Open Targets associations for SYNE3 are neuroticism measurement, PR interval, protein measurement, diffuse plaque measurement and PHF-tau measurement.
How long is the SYNE3 protein?
The Homo sapiens SYNE3 protein (UniProt Q6ZMZ3) is 975 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZMZ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZMZ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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