Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
Homo sapiens — UniProt Q6ZN16
Data last refreshed: (UniProt release unknown)
Key facts
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15) is a protein from Homo sapiens identified by UniProt accession Q6ZN16, 1313 residues long. MolForge cross-references it against 4 known binders and 91 disease associations.
- UniProt accession: Q6ZN16; gene symbol MAP3K15.
- Organism: Homo sapiens.
- Length: 1313 amino acids.
- Top disease associations (Open Targets): HbA1c measurement, glucose measurement and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase 15 |
|---|---|
| UniProt accession | Q6ZN16 |
| Gene | MAP3K15 |
| Organism | Homo sapiens |
| Length | 1313 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.55
- glucose measurement · score 0.54
- neurodegenerative disease · score 0.41
- pyruvate dehydrogenase E1-alpha deficiency · score 0.19
- diabetes mellitus · score 0.17
- Neurodevelopmental disorder · score 0.12
- focal segmental glomerulosclerosis · score 0.07
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.07
- IGA glomerulonephritis · score 0.07
- glomerulopathy with fibronectin deposits 2 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZN16-F1 | alphafold | PREDICTED | 74.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZN16.
Amino-acid sequence (1313 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAP3K15?
The strongest Open Targets associations for MAP3K15 are HbA1c measurement, glucose measurement, neurodegenerative disease, pyruvate dehydrogenase E1-alpha deficiency and diabetes mellitus.
How long is the MAP3K15 protein?
The Homo sapiens MAP3K15 protein (UniProt Q6ZN16) is 1313 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZN16 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZN16 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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