Protein lin-28 homolog B (LIN28B)
Homo sapiens — UniProt Q6ZN17
Data last refreshed: (UniProt release unknown)
Key facts
Protein lin-28 homolog B (LIN28B) is a protein from Homo sapiens identified by UniProt accession Q6ZN17, 250 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.
- UniProt accession: Q6ZN17; gene symbol LIN28B.
- Organism: Homo sapiens.
- Length: 250 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist circumference, age at menarche and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein lin-28 homolog B |
|---|---|
| UniProt accession | Q6ZN17 |
| Gene | LIN28B |
| Organism | Homo sapiens |
| Length | 250 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (200)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.49
- age at menarche · score 0.49
- body height · score 0.49
- digit length ratio · score 0.47
- puberty onset measurement · score 0.46
- body fat distribution · score 0.46
- forced expiratory volume · score 0.45
- vital capacity · score 0.45
- heel bone mineral density · score 0.45
- testosterone measurement · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZN17-F1 | alphafold | PREDICTED | 73.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZN17.
Amino-acid sequence (250 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIN28B?
The strongest Open Targets associations for LIN28B are BMI-adjusted waist circumference, age at menarche, body height, digit length ratio and puberty onset measurement.
How long is the LIN28B protein?
The Homo sapiens LIN28B protein (UniProt Q6ZN17) is 250 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZN17 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZN17 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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