Metastasis-associated in colon cancer protein 1 (MACC1)
Homo sapiens — UniProt Q6ZN28
Data last refreshed: (UniProt release unknown)
Key facts
Metastasis-associated in colon cancer protein 1 (MACC1) is a protein from Homo sapiens identified by UniProt accession Q6ZN28, 852 residues long. MolForge cross-references it against 0 known binders and 230 disease associations.
- UniProt accession: Q6ZN28; gene symbol MACC1.
- Organism: Homo sapiens.
- Length: 852 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, alkaline phosphatase measurement and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Metastasis-associated in colon cancer protein 1 |
|---|---|
| UniProt accession | Q6ZN28 |
| Gene | MACC1 |
| Organism | Homo sapiens |
| Length | 852 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (230)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.35
- alkaline phosphatase measurement · score 0.33
- PHF-tau measurement · score 0.32
- adolescent idiopathic scoliosis · score 0.29
- blood phosphate measurement · score 0.25
- lung adenocarcinoma · score 0.22
- hepatocellular carcinoma · score 0.21
- non-small cell lung carcinoma · score 0.21
- protein measurement · score 0.21
- esophageal squamous cell carcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZN28-F1 | alphafold | PREDICTED | 71.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZN28.
Amino-acid sequence (852 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MACC1?
The strongest Open Targets associations for MACC1 are heel bone mineral density, alkaline phosphatase measurement, PHF-tau measurement, adolescent idiopathic scoliosis and blood phosphate measurement.
How long is the MACC1 protein?
The Homo sapiens MACC1 protein (UniProt Q6ZN28) is 852 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZN28 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZN28 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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