Netrin receptor UNC5A (UNC5A)
Homo sapiens — UniProt Q6ZN44
Data last refreshed: (UniProt release unknown)
Key facts
Netrin receptor UNC5A (UNC5A) is a protein from Homo sapiens identified by UniProt accession Q6ZN44, 842 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q6ZN44; gene symbol UNC5A.
- Organism: Homo sapiens.
- Length: 842 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, low grade glioma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Netrin receptor UNC5A |
|---|---|
| UniProt accession | Q6ZN44 |
| Gene | UNC5A |
| Organism | Homo sapiens |
| Length | 842 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.24
- low grade glioma · score 0.23
- ovarian cancer · score 0.23
- obsessive-compulsive disorder · score 0.19
- cutaneous melanoma · score 0.19
- thyroid gland adenocarcinoma · score 0.18
- esophageal cancer · score 0.15
- head and neck squamous cell carcinoma · score 0.12
- non-small cell lung carcinoma · score 0.09
- cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZN44-F1 | alphafold | PREDICTED | 77.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZN44.
Amino-acid sequence (842 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNC5A?
The strongest Open Targets associations for UNC5A are glioblastoma multiforme, low grade glioma, ovarian cancer, obsessive-compulsive disorder and cutaneous melanoma.
How long is the UNC5A protein?
The Homo sapiens UNC5A protein (UniProt Q6ZN44) is 842 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZN44 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZN44 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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