Differentially expressed in FDCP 8 homolog (DEF8)
Homo sapiens — UniProt Q6ZN54
Data last refreshed: (UniProt release unknown)
Key facts
Differentially expressed in FDCP 8 homolog (DEF8) is a protein from Homo sapiens identified by UniProt accession Q6ZN54, 512 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q6ZN54; gene symbol DEF8.
- Organism: Homo sapiens.
- Length: 512 amino acids.
- Top disease associations (Open Targets): complex cortical dysplasia with other brain malformations 1, squamous cell carcinoma and skin carcinoma in situ.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Differentially expressed in FDCP 8 homolog |
|---|---|
| UniProt accession | Q6ZN54 |
| Gene | DEF8 |
| Organism | Homo sapiens |
| Length | 512 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- complex cortical dysplasia with other brain malformations 1 · score 0.34
- squamous cell carcinoma · score 0.31
- skin carcinoma in situ · score 0.31
- hair color · score 0.30
- white matter microstructure measurement · score 0.30
- neoplasm · score 0.28
- skin pigmentation · score 0.27
- basal cell carcinoma · score 0.27
- reticulocyte count · score 0.26
- Vitiligo · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZN54-F1 | alphafold | PREDICTED | 75.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZN54.
Amino-acid sequence (512 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEF8?
The strongest Open Targets associations for DEF8 are complex cortical dysplasia with other brain malformations 1, squamous cell carcinoma, skin carcinoma in situ, hair color and white matter microstructure measurement.
How long is the DEF8 protein?
The Homo sapiens DEF8 protein (UniProt Q6ZN54) is 512 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZN54 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZN54 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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