Guanylate-binding protein 6 (GBP6)
Homo sapiens — UniProt Q6ZN66
Data last refreshed: (UniProt release unknown)
Key facts
Guanylate-binding protein 6 (GBP6) is a protein from Homo sapiens identified by UniProt accession Q6ZN66, 633 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q6ZN66; gene symbol GBP6.
- Organism: Homo sapiens.
- Length: 633 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, non-small cell lung carcinoma and psoriasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanylate-binding protein 6 |
|---|---|
| UniProt accession | Q6ZN66 |
| Gene | GBP6 |
| Organism | Homo sapiens |
| Length | 633 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.23
- non-small cell lung carcinoma · score 0.03
- psoriasis · score 0.02
- carcinoma of liver and intrahepatic biliary tract · score 0.02
- oral squamous cell carcinoma · score 0.02
- infection · score 0.01
- infect · score 0.01
- inclusion body myositis · score 0.01
- cancer · score 0.01
- head and neck squamous cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZN66-F1 | alphafold | PREDICTED | 89.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZN66.
Amino-acid sequence (633 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GBP6?
The strongest Open Targets associations for GBP6 are PHF-tau measurement, non-small cell lung carcinoma, psoriasis, carcinoma of liver and intrahepatic biliary tract and oral squamous cell carcinoma.
How long is the GBP6 protein?
The Homo sapiens GBP6 protein (UniProt Q6ZN66) is 633 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZN66 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZN66 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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