E3 ubiquitin-protein ligase Arkadia (RNF111)
Homo sapiens — UniProt Q6ZNA4
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase Arkadia (RNF111) is a protein from Homo sapiens identified by UniProt accession Q6ZNA4, 994 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q6ZNA4; gene symbol RNF111.
- Organism: Homo sapiens.
- Length: 994 amino acids.
- Top disease associations (Open Targets): schizophrenia, cigarettes per day measurement and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase Arkadia |
|---|---|
| UniProt accession | Q6ZNA4 |
| Gene | RNF111 |
| Organism | Homo sapiens |
| Length | 994 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.40
- cigarettes per day measurement · score 0.34
- neurodegenerative disease · score 0.33
- apolipoprotein A 1 measurement · score 0.28
- Jeune syndrome · score 0.26
- high density lipoprotein particle size measurement · score 0.24
- acute myeloid leukemia · score 0.21
- breast adenocarcinoma · score 0.18
- gonorrhea · score 0.09
- breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNA4-F1 | alphafold | PREDICTED | 46.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNA4.
Amino-acid sequence (994 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF111?
The strongest Open Targets associations for RNF111 are schizophrenia, cigarettes per day measurement, neurodegenerative disease, apolipoprotein A 1 measurement and Jeune syndrome.
How long is the RNF111 protein?
The Homo sapiens RNF111 protein (UniProt Q6ZNA4) is 994 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNA4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNA4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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