Ferric reductase 1 (FRRS1)
Homo sapiens — UniProt Q6ZNA5
Data last refreshed: (UniProt release unknown)
Key facts
Ferric reductase 1 (FRRS1) is a protein from Homo sapiens identified by UniProt accession Q6ZNA5, 592 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q6ZNA5; gene symbol FRRS1.
- Organism: Homo sapiens.
- Length: 592 amino acids.
- Top disease associations (Open Targets): aortic stenosis, Abnormal heart morphology and aortic valve calcification.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ferric reductase 1 |
|---|---|
| UniProt accession | Q6ZNA5 |
| Gene | FRRS1 |
| Organism | Homo sapiens |
| Length | 592 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- aortic stenosis · score 0.08
- Abnormal heart morphology · score 0.08
- aortic valve calcification · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.06
- heart valve disease · score 0.06
- aortic root size · score 0.06
- congenital anomaly of the great arteries · score 0.06
- Bicuspid aortic valve · score 0.06
- body height · score 0.05
- bulimia nervosa · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNA5-F1 | alphafold | PREDICTED | 88.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNA5.
Amino-acid sequence (592 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FRRS1?
The strongest Open Targets associations for FRRS1 are aortic stenosis, Abnormal heart morphology, aortic valve calcification, serum gamma-glutamyl transferase measurement and heart valve disease.
How long is the FRRS1 protein?
The Homo sapiens FRRS1 protein (UniProt Q6ZNA5) is 592 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNA5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNA5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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