NF-X1-type zinc finger protein NFXL1 (NFXL1)
Homo sapiens — UniProt Q6ZNB6
Data last refreshed: (UniProt release unknown)
Key facts
NF-X1-type zinc finger protein NFXL1 (NFXL1) is a protein from Homo sapiens identified by UniProt accession Q6ZNB6, 911 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q6ZNB6; gene symbol NFXL1.
- Organism: Homo sapiens.
- Length: 911 amino acids.
- Top disease associations (Open Targets): Gollop-Wolfgang complex, tibia, hypoplasia or aplasia of, with polydactyly and Blount disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NF-X1-type zinc finger protein NFXL1 |
|---|---|
| UniProt accession | Q6ZNB6 |
| Gene | NFXL1 |
| Organism | Homo sapiens |
| Length | 911 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- Gollop-Wolfgang complex · score 0.05
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.05
- Blount disease · score 0.05
- acheiropody · score 0.04
- syndactyly type 4 · score 0.04
- Acheiropodia · score 0.04
- Acromesomelic dysplasia, Hunter-Thomson type · score 0.04
- acromesomelic dysplasia 2C, Hunter-Thompson type · score 0.04
- laurin-Sandrow syndrome · score 0.04
- Absent tibia - polydactyly · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNB6-F1 | alphafold | PREDICTED | 73.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNB6.
Amino-acid sequence (911 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NFXL1?
The strongest Open Targets associations for NFXL1 are Gollop-Wolfgang complex, tibia, hypoplasia or aplasia of, with polydactyly, Blount disease, acheiropody and syndactyly type 4.
How long is the NFXL1 protein?
The Homo sapiens NFXL1 protein (UniProt Q6ZNB6) is 911 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNB6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNB6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.