Membrane-bound glycerophospholipid O-acyltransferase 1 (MBOAT1)
Homo sapiens — UniProt Q6ZNC8
Data last refreshed: (UniProt release unknown)
Key facts
Membrane-bound glycerophospholipid O-acyltransferase 1 (MBOAT1) is a protein from Homo sapiens identified by UniProt accession Q6ZNC8, 495 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q6ZNC8; gene symbol MBOAT1.
- Organism: Homo sapiens.
- Length: 495 amino acids.
- Top disease associations (Open Targets): lymphocyte count, lymphocyte percentage of leukocytes and response to angiotensin-converting enzyme inhibitor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane-bound glycerophospholipid O-acyltransferase 1 |
|---|---|
| UniProt accession | Q6ZNC8 |
| Gene | MBOAT1 |
| Organism | Homo sapiens |
| Length | 495 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.36
- lymphocyte percentage of leukocytes · score 0.35
- response to angiotensin-converting enzyme inhibitor · score 0.31
- Red cell distribution width · score 0.31
- electrocardiography · score 0.30
- high density lipoprotein cholesterol measurement · score 0.28
- urate measurement · score 0.21
- bone density · score 0.21
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNC8-F1 | alphafold | PREDICTED | 89.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNC8.
Amino-acid sequence (495 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MBOAT1?
The strongest Open Targets associations for MBOAT1 are lymphocyte count, lymphocyte percentage of leukocytes, response to angiotensin-converting enzyme inhibitor, Red cell distribution width and electrocardiography.
How long is the MBOAT1 protein?
The Homo sapiens MBOAT1 protein (UniProt Q6ZNC8) is 495 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNC8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNC8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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