RUN and FYVE domain-containing protein 4 (RUFY4)
Homo sapiens — UniProt Q6ZNE9
Data last refreshed: (UniProt release unknown)
Key facts
RUN and FYVE domain-containing protein 4 (RUFY4) is a protein from Homo sapiens identified by UniProt accession Q6ZNE9, 571 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q6ZNE9; gene symbol RUFY4.
- Organism: Homo sapiens.
- Length: 571 amino acids.
- Top disease associations (Open Targets): neutrophil count, reticulocyte count and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RUN and FYVE domain-containing protein 4 |
|---|---|
| UniProt accession | Q6ZNE9 |
| Gene | RUFY4 |
| Organism | Homo sapiens |
| Length | 571 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.17
- reticulocyte count · score 0.13
- erythrocyte count · score 0.12
- reticulocyte measurement · score 0.11
- mean platelet volume · score 0.11
- type 2 diabetes mellitus · score 0.10
- hemoglobin measurement · score 0.10
- appendicular lean mass · score 0.10
- forced expiratory volume · score 0.10
- body height · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNE9-F1 | alphafold | PREDICTED | 67.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNE9.
Amino-acid sequence (571 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RUFY4?
The strongest Open Targets associations for RUFY4 are neutrophil count, reticulocyte count, erythrocyte count, reticulocyte measurement and mean platelet volume.
How long is the RUFY4 protein?
The Homo sapiens RUFY4 protein (UniProt Q6ZNE9) is 571 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNE9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNE9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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