KRAB domain-containing protein 2 (KRABD2)
Homo sapiens — UniProt Q6ZNG9
Data last refreshed: (UniProt release unknown)
Key facts
KRAB domain-containing protein 2 (KRABD2) is a protein from Homo sapiens identified by UniProt accession Q6ZNG9, 492 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q6ZNG9; gene symbol KRABD2.
- Organism: Homo sapiens.
- Length: 492 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular hemoglobin concentration and apolipoprotein A 1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | KRAB domain-containing protein 2 |
|---|---|
| UniProt accession | Q6ZNG9 |
| Gene | KRABD2 |
| Organism | Homo sapiens |
| Length | 492 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- mean corpuscular hemoglobin concentration · score 0.03
- apolipoprotein A 1 measurement · score 0.03
- erythrocyte count · score 0.02
- high density lipoprotein cholesterol measurement · score 0.02
- acute myeloid leukemia · score 0.01
- bladder transitional cell carcinoma · score 0.00
- melanoma · score 0.00
- Crohn's disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNG9-F1 | alphafold | PREDICTED | 73.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNG9.
Amino-acid sequence (492 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRABD2?
The strongest Open Targets associations for KRABD2 are neurodegenerative disease, mean corpuscular hemoglobin concentration, apolipoprotein A 1 measurement, erythrocyte count and high density lipoprotein cholesterol measurement.
How long is the KRABD2 protein?
The Homo sapiens KRABD2 protein (UniProt Q6ZNG9) is 492 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNG9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNG9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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