TRAF-interacting protein with FHA domain-containing protein B (TIFAB)
Homo sapiens — UniProt Q6ZNK6
Data last refreshed: (UniProt release unknown)
Key facts
TRAF-interacting protein with FHA domain-containing protein B (TIFAB) is a protein from Homo sapiens identified by UniProt accession Q6ZNK6, 161 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q6ZNK6; gene symbol TIFAB.
- Organism: Homo sapiens.
- Length: 161 amino acids.
- Top disease associations (Open Targets): eye morphology measurement, heel bone mineral density and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TRAF-interacting protein with FHA domain-containing protein B |
|---|---|
| UniProt accession | Q6ZNK6 |
| Gene | TIFAB |
| Organism | Homo sapiens |
| Length | 161 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- eye morphology measurement · score 0.15
- heel bone mineral density · score 0.13
- mean platelet volume · score 0.12
- acute myeloid leukemia · score 0.10
- benign prostatic hyperplasia · score 0.09
- lower urinary tract symptom · score 0.09
- myelodysplastic syndrome · score 0.08
- lean body mass · score 0.08
- appendicular lean mass · score 0.08
- fat body mass · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNK6-F1 | alphafold | PREDICTED | 89.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNK6.
Amino-acid sequence (161 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TIFAB?
The strongest Open Targets associations for TIFAB are eye morphology measurement, heel bone mineral density, mean platelet volume, acute myeloid leukemia and benign prostatic hyperplasia.
How long is the TIFAB protein?
The Homo sapiens TIFAB protein (UniProt Q6ZNK6) is 161 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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