FYVE, RhoGEF and PH domain-containing protein 5 (FGD5)
Homo sapiens — UniProt Q6ZNL6
Data last refreshed: (UniProt release unknown)
Key facts
FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) is a protein from Homo sapiens identified by UniProt accession Q6ZNL6, 1462 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q6ZNL6; gene symbol FGD5.
- Organism: Homo sapiens.
- Length: 1462 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, diastolic blood pressure and coronary artery disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FYVE, RhoGEF and PH domain-containing protein 5 |
|---|---|
| UniProt accession | Q6ZNL6 |
| Gene | FGD5 |
| Organism | Homo sapiens |
| Length | 1462 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.47
- diastolic blood pressure · score 0.46
- coronary artery disease · score 0.44
- hemoglobin measurement · score 0.41
- hypertension · score 0.40
- hematocrit · score 0.40
- mean arterial pressure · score 0.40
- cardiovascular disease · score 0.38
- pulse pressure measurement · score 0.37
- myocardial infarction · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNL6-F1 | alphafold | PREDICTED | 53.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNL6.
Amino-acid sequence (1462 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FGD5?
The strongest Open Targets associations for FGD5 are systolic blood pressure, diastolic blood pressure, coronary artery disease, hemoglobin measurement and hypertension.
How long is the FGD5 protein?
The Homo sapiens FGD5 protein (UniProt Q6ZNL6) is 1462 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNL6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNL6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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