Sperm-associated microtubule inner protein 10 (SPMIP10)
Homo sapiens — UniProt Q6ZNM6
Data last refreshed: (UniProt release unknown)
Key facts
Sperm-associated microtubule inner protein 10 (SPMIP10) is a protein from Homo sapiens identified by UniProt accession Q6ZNM6, 134 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q6ZNM6; gene symbol SPMIP10.
- Organism: Homo sapiens.
- Length: 134 amino acids.
- Top disease associations (Open Targets): adult-onset autosomal dominant demyelinating leukodystrophy, Adult-onset autosomal dominant leukodystrophy and colorectal cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm-associated microtubule inner protein 10 |
|---|---|
| UniProt accession | Q6ZNM6 |
| Gene | SPMIP10 |
| Organism | Homo sapiens |
| Length | 134 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- adult-onset autosomal dominant demyelinating leukodystrophy · score 0.34
- Adult-onset autosomal dominant leukodystrophy · score 0.34
- colorectal cancer · score 0.23
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failure 3 · score 0.06
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 7 · score 0.06
- spermatogenic failure 29 · score 0.06
- hemoglobin measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNM6-F1 | alphafold | PREDICTED | 59.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNM6.
Amino-acid sequence (134 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPMIP10?
The strongest Open Targets associations for SPMIP10 are adult-onset autosomal dominant demyelinating leukodystrophy, Adult-onset autosomal dominant leukodystrophy, colorectal cancer, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the SPMIP10 protein?
The Homo sapiens SPMIP10 protein (UniProt Q6ZNM6) is 134 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNM6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNM6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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