Transmembrane protein 91 (TMEM91)
Homo sapiens — UniProt Q6ZNR0
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 91 (TMEM91) is a protein from Homo sapiens identified by UniProt accession Q6ZNR0, 172 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q6ZNR0; gene symbol TMEM91.
- Organism: Homo sapiens.
- Length: 172 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Meckel syndrome and Joubert syndrome and related disorders.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 91 |
|---|---|
| UniProt accession | Q6ZNR0 |
| Gene | TMEM91 |
| Organism | Homo sapiens |
| Length | 172 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.53
- Meckel syndrome · score 0.49
- Joubert syndrome and related disorders · score 0.46
- Encephalopathy · score 0.42
- immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome · score 0.42
- Camurati-Engelmann disease · score 0.36
- inflammatory bowel disease, immunodeficiency, and encephalopathy · score 0.35
- blood protein measurement · score 0.30
- coronary artery disease · score 0.24
- colorectal cancer · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZNR0-F1 | alphafold | PREDICTED | 58.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZNR0.
Amino-acid sequence (172 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM91?
The strongest Open Targets associations for TMEM91 are Joubert syndrome, Meckel syndrome, Joubert syndrome and related disorders, Encephalopathy and immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome.
How long is the TMEM91 protein?
The Homo sapiens TMEM91 protein (UniProt Q6ZNR0) is 172 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZNR0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZNR0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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