Forkhead box protein I2 (FOXI2)
Homo sapiens — UniProt Q6ZQN5
Data last refreshed: (UniProt release unknown)
Key facts
Forkhead box protein I2 (FOXI2) is a protein from Homo sapiens identified by UniProt accession Q6ZQN5, 318 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q6ZQN5; gene symbol FOXI2.
- Organism: Homo sapiens.
- Length: 318 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, bladder disease and metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Forkhead box protein I2 |
|---|---|
| UniProt accession | Q6ZQN5 |
| Gene | FOXI2 |
| Organism | Homo sapiens |
| Length | 318 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- bladder disease · score 0.24
- metabolite measurement · score 0.10
- nonpapillary renal cell carcinoma · score 0.08
- MODY · score 0.07
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.05
- hyperproinsulinemia · score 0.05
- Down syndrome · score 0.05
- exercise-induced hyperinsulinism · score 0.04
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZQN5-F1 | alphafold | PREDICTED | 61.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZQN5.
Amino-acid sequence (318 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FOXI2?
The strongest Open Targets associations for FOXI2 are neurodegenerative disease, bladder disease, metabolite measurement, nonpapillary renal cell carcinoma and MODY.
How long is the FOXI2 protein?
The Homo sapiens FOXI2 protein (UniProt Q6ZQN5) is 318 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZQN5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZQN5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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