Cilia- and flagella-associated protein 77 (CFAP77)
Homo sapiens — UniProt Q6ZQR2
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 77 (CFAP77) is a protein from Homo sapiens identified by UniProt accession Q6ZQR2, 320 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q6ZQR2; gene symbol CFAP77.
- Organism: Homo sapiens.
- Length: 320 amino acids.
- Top disease associations (Open Targets): Irritability, irritability measurement and mood instability measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 77 |
|---|---|
| UniProt accession | Q6ZQR2 |
| Gene | CFAP77 |
| Organism | Homo sapiens |
| Length | 320 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- Irritability · score 0.31
- irritability measurement · score 0.31
- mood instability measurement · score 0.31
- platelet count · score 0.17
- blood protein measurement · score 0.10
- central nervous system cancer · score 0.06
- Red cell distribution width · score 0.04
- protein measurement · score 0.04
- pancreatic adenocarcinoma · score 0.03
- angiopoietin-1 receptor measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZQR2-F1 | alphafold | PREDICTED | 73.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZQR2.
Amino-acid sequence (320 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP77?
The strongest Open Targets associations for CFAP77 are Irritability, irritability measurement, mood instability measurement, platelet count and blood protein measurement.
How long is the CFAP77 protein?
The Homo sapiens CFAP77 protein (UniProt Q6ZQR2) is 320 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZQR2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZQR2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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