Leucine-rich repeat-containing protein 74B (LRRC74B)
Homo sapiens — UniProt Q6ZQY2
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 74B (LRRC74B) is a protein from Homo sapiens identified by UniProt accession Q6ZQY2, 392 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q6ZQY2; gene symbol LRRC74B.
- Organism: Homo sapiens.
- Length: 392 amino acids.
- Top disease associations (Open Targets): Inguinal hernia, metabolite measurement and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 74B |
|---|---|
| UniProt accession | Q6ZQY2 |
| Gene | LRRC74B |
| Organism | Homo sapiens |
| Length | 392 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- Inguinal hernia · score 0.18
- metabolite measurement · score 0.09
- adolescent idiopathic scoliosis · score 0.05
- psoriasis · score 0.02
- squamous cell carcinoma · score 0.01
- gastric carcinoma · score 0.00
- immature platelet fraction · score 0.00
- endometrial carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZQY2-F1 | alphafold | PREDICTED | 84.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZQY2.
Amino-acid sequence (392 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC74B?
The strongest Open Targets associations for LRRC74B are Inguinal hernia, metabolite measurement, adolescent idiopathic scoliosis, psoriasis and squamous cell carcinoma.
How long is the LRRC74B protein?
The Homo sapiens LRRC74B protein (UniProt Q6ZQY2) is 392 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZQY2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZQY2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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