Pleckstrin homology domain-containing family G member 7 (PLEKHG7)
Homo sapiens — UniProt Q6ZR37
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) is a protein from Homo sapiens identified by UniProt accession Q6ZR37, 691 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q6ZR37; gene symbol PLEKHG7.
- Organism: Homo sapiens.
- Length: 691 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, intelligence and brain volume measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family G member 7 |
|---|---|
| UniProt accession | Q6ZR37 |
| Gene | PLEKHG7 |
| Organism | Homo sapiens |
| Length | 691 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- intelligence · score 0.31
- brain volume measurement · score 0.28
- cognitive function measurement · score 0.23
- self reported educational attainment · score 0.23
- appendicular lean mass · score 0.20
- myeloid white cell count · score 0.16
- DNA methylation · score 0.08
- eosinophil count · score 0.08
- erythrocyte count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZR37-F1 | alphafold | PREDICTED | 62.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZR37.
Amino-acid sequence (691 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHG7?
The strongest Open Targets associations for PLEKHG7 are neurodegenerative disease, intelligence, brain volume measurement, cognitive function measurement and self reported educational attainment.
How long is the PLEKHG7 protein?
The Homo sapiens PLEKHG7 protein (UniProt Q6ZR37) is 691 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZR37 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZR37 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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