Retrotransposon Gag-like protein 4 (RTL4)
Homo sapiens — UniProt Q6ZR62
Data last refreshed: (UniProt release unknown)
Key facts
Retrotransposon Gag-like protein 4 (RTL4) is a protein from Homo sapiens identified by UniProt accession Q6ZR62, 310 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q6ZR62; gene symbol RTL4.
- Organism: Homo sapiens.
- Length: 310 amino acids.
- Top disease associations (Open Targets): hypertension, attention deficit hyperactivity disorder and Tourette syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Retrotransposon Gag-like protein 4 |
|---|---|
| UniProt accession | Q6ZR62 |
| Gene | RTL4 |
| Organism | Homo sapiens |
| Length | 310 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- hypertension · score 0.10
- attention deficit hyperactivity disorder · score 0.07
- Tourette syndrome · score 0.05
- Potocki-Lupski syndrome · score 0.05
- attention deficit-hyperactivity disorder 8 · score 0.04
- glycogen storage disease due to glycogen branching enzyme deficiency · score 0.04
- X-linked dominant intellectual disability - epilepsy syndrome · score 0.03
- papillary thyroid carcinoma · score 0.03
- erythrocyte count · score 0.02
- hemoglobin measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZR62-F1 | alphafold | PREDICTED | 48.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZR62.
Amino-acid sequence (310 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RTL4?
The strongest Open Targets associations for RTL4 are hypertension, attention deficit hyperactivity disorder, Tourette syndrome, Potocki-Lupski syndrome and attention deficit-hyperactivity disorder 8.
How long is the RTL4 protein?
The Homo sapiens RTL4 protein (UniProt Q6ZR62) is 310 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZR62 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZR62 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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