RING finger protein 207 (RNF207)

Homo sapiens — UniProt Q6ZRF8

Gene: RNF207Homo sapiensSwissProt reviewed

About RING finger protein 207

RING finger protein 207 (RNF207) is a protein from Homo sapiens identified by UniProt accession Q6ZRF8, 634 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein nameRING finger protein 207
UniProt accessionQ6ZRF8
GeneRNF207
OrganismHomo sapiens
Length634 residues
Molecular weight—
EC numbers—
Target class—
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (26)

Diseases linked to this target (Open Targets).

  • electrocardiography · score 0.40
  • QT interval · score 0.37
  • neurodegenerative disease · score 0.34
  • pulse pressure measurement · score 0.28
  • Prolonged QT interval · score 0.27
  • mean corpuscular volume · score 0.24
  • ulcerative colitis · score 0.21
  • T wave morphology measurement · score 0.21
  • heart rate · score 0.15
  • TPE interval measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-Q6ZRF8-F1alphafoldPREDICTED75.27—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZRF8.

Amino-acid sequence (634 residues)

MSGAIFGPLE GPSSLDAPSI HPLVCPLCHV QYERPCLLDC FHDFCAGCLR GRATDGRLTC PLCQHQTVLK GPSGLPPVDR LLQFLVDSSG DGVEAVRCAN CDLECSEQDV ETTYFCNTCG QPLCARCRDE THRARMFARH DIVALGQRSR DVPQKCTLHA EPYLLFSTDK KLLLCIRCFR DMQKESRAHC VDLESAYVQG CERLEQAVLA VKALQTATRE AIALLQAMVE EVRHSAAEEE DAIHALFGSM QDRLAERKAL LLQAVQSQYE EKDKAFKEQL SHLATLLPTL QVHLVICSSF LSLANKAEFL DLGYELMERL QGIVTRPHHL RPIQSSKIAS DHRAEFARCL EPLLLLGPRR VAAAASGANT LAGGLGPKAL TGPHCPSPVG KMSGSPVQKP TLHRSISTKV LLAEGENTPF AEHCRHYEDS YRHLQAEMQS LKDQVQELHR DLTKHHSLIK AEIMGDVLHK SLQLDVQIAS EHASLEGMRV VFQEIWEEAY QRVANEQEIY EAQLHDLLQL RQENAYLTTI TKQITPYVRS IAKVKERLEP RFQAPVDEQS ESLQNTHDDS RNNAASARNN PGSVPEKREK TSEPKGNSWA PNGLSEEPLL KNMDHHRSKQ KNGGDVPTWR EHPT

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Quick facts

UniProtQ6ZRF8
GeneRNF207
OrganismHomo sapiens
Length634
Binders0
Diseases26
View on UniProt