TLC domain-containing protein 5 (TLCD5)
Homo sapiens — UniProt Q6ZRR5
Data last refreshed: (UniProt release unknown)
Key facts
TLC domain-containing protein 5 (TLCD5) is a protein from Homo sapiens identified by UniProt accession Q6ZRR5, 245 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q6ZRR5; gene symbol TLCD5.
- Organism: Homo sapiens.
- Length: 245 amino acids.
- Top disease associations (Open Targets): open-angle glaucoma, platelet count and intraocular pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TLC domain-containing protein 5 |
|---|---|
| UniProt accession | Q6ZRR5 |
| Gene | TLCD5 |
| Organism | Homo sapiens |
| Length | 245 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- open-angle glaucoma · score 0.37
- platelet count · score 0.34
- intraocular pressure measurement · score 0.29
- leukocyte count · score 0.24
- glaucoma · score 0.23
- lean body mass · score 0.23
- mean arterial pressure · score 0.22
- body height · score 0.19
- cutaneous melanoma · score 0.19
- fat body mass · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZRR5-F1 | alphafold | PREDICTED | 94.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZRR5.
Amino-acid sequence (245 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TLCD5?
The strongest Open Targets associations for TLCD5 are open-angle glaucoma, platelet count, intraocular pressure measurement, leukocyte count and glaucoma.
How long is the TLCD5 protein?
The Homo sapiens TLCD5 protein (UniProt Q6ZRR5) is 245 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZRR5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZRR5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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