Leucine-rich repeat-containing protein 9 (LRRC9)
Homo sapiens — UniProt Q6ZRR7
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 9 (LRRC9) is a protein from Homo sapiens identified by UniProt accession Q6ZRR7, 1453 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q6ZRR7; gene symbol LRRC9.
- Organism: Homo sapiens.
- Length: 1453 amino acids.
- Top disease associations (Open Targets): mortality, donor genotype effect measurement and response to allogeneic hematopoietic stem cell transplant.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 9 |
|---|---|
| UniProt accession | Q6ZRR7 |
| Gene | LRRC9 |
| Organism | Homo sapiens |
| Length | 1453 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- mortality · score 0.08
- donor genotype effect measurement · score 0.08
- response to allogeneic hematopoietic stem cell transplant · score 0.08
- age-related hearing impairment · score 0.04
- calcium measurement · score 0.03
- Crohn's disease · score 0.01
- major depressive disorder · score 0.01
- neuroblastoma · score 0.00
- neoplasm · score 0.00
- prostate adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZRR7-F1 | alphafold | PREDICTED | 80.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZRR7.
Amino-acid sequence (1453 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC9?
The strongest Open Targets associations for LRRC9 are mortality, donor genotype effect measurement, response to allogeneic hematopoietic stem cell transplant, age-related hearing impairment and calcium measurement.
How long is the LRRC9 protein?
The Homo sapiens LRRC9 protein (UniProt Q6ZRR7) is 1453 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZRR7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZRR7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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