Chromatin remodeling protein SRCAP (SRCAP)

Homo sapiens — UniProt Q6ZRS2

Gene: SRCAPHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Chromatin remodeling protein SRCAP (SRCAP) is a protein from Homo sapiens identified by UniProt accession Q6ZRS2, 3230 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.

UniProt accession: Q6ZRS2; gene symbol SRCAP.
Organism: Homo sapiens.
Length: 3230 amino acids.
Top disease associations (Open Targets): Floating-Harbor syndrome, neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities and genetic disorder.
3D structure: AlphaFold model available.

Target properties

Protein name	Chromatin remodeling protein SRCAP
UniProt accession	Q6ZRS2
Gene	SRCAP
Organism	Homo sapiens
Length	3230 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (131)

Diseases linked to this target (Open Targets).

Floating-Harbor syndrome · score 0.79
neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities · score 0.63
genetic disorder · score 0.53
Neurodevelopmental disorder · score 0.51
neurodegenerative disease · score 0.37
complex neurodevelopmental disorder · score 0.37
Neurodevelopmental delay · score 0.35
Rare genetic intellectual disability · score 0.26
Intellectual disability, moderate · score 0.26
autism spectrum disorder · score 0.16

3D Structure (10)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZRS2-F1	alphafold	PREDICTED	54.92	—
AF-Q6ZRS2-F2	alphafold	PREDICTED	51.35	—
AF-Q6ZRS2-F3	alphafold	PREDICTED	47.71	—
AF-Q6ZRS2-F9	alphafold	PREDICTED	47.64	—
AF-Q6ZRS2-F8	alphafold	PREDICTED	47.40	—
AF-Q6ZRS2-F10	alphafold	PREDICTED	47.37	—
AF-Q6ZRS2-F4	alphafold	PREDICTED	47.18	—
AF-Q6ZRS2-F6	alphafold	PREDICTED	47.07	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZRS2.

Amino-acid sequence (3230 residues)

MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH IAQDSSLDGP PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA KHEAEIETRI AELRKEGFWS LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD FAQERRWKRG VARKVVRMVI RHHEEQRQKE ERARREEQAK LRRIASTMAK DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT EKYSDLLSQS LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP SQTPSSHDSD TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD EEFTANEEEA EDEEDTIAAE EQLEGEVDHA MELSELAREG ELSMEELLQQ YAGAYAPGSG SSEDEDEDEV DANSSDCEPE GPVEAEEPPQ EDSSSQSDSV EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA DEEEEDDDFG VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT IQTISLLAHL ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG AQKERKLKRQ GWTKPNAFHV CITSYKLVLQ DHQAFRRKNW RYLILDEAQN IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN SLMELWSLMH FLMPHVFQSH REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR VKVDVEKQMP KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG LEGRVSRYEA DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP VPKQEGRTVV VVNNPRAPLG PVPVRPPPGP ELSAQPTPGP VPQVLPASLM VSASPAGPPL IPASRPPGPV LLPPLQPNSG SLPQVLPSPL GVLSGTSRPP TPTLSLKPTP PAPVRLSPAP PPGSSSLLKP LTVPPGYTFP PAAATTTSTT TATATTTAVP APTPAPQRLI LSPDMQARLP SGEVVSIGQL ASLAQRPVAN AGGSKPLTFQ IQGNKLTLTG AQVRQLAVGQ PRPLQRNVVH LVSAGGQHHL ISQPAHVALI QAVAPTPGPT PVSVLPSSTP STTPAPTGLS LPLAANQVPP TMVNNTGVVK IVVRQAPRDG LTPVPPLAPA PRPPSSGLPA VLNPRPTLTP GRLPTPTLGT ARAPMPTPTL VRPLLKLVHS PSPEVSASAP GAAPLTISSP LHVPSSLPGP ASSPMPIPNS SPLASPVSST VSVPLSSSLP ISVPTTLPAP ASAPLTIPIS APLTVSASGP ALLTSVTPPL APVVPAAPGP PSLAPSGASP SASALTLGLA TAPSLSSSQT PGHPLLLAPT SSHVPGLNST VAPACSPVLV PASALASPFP SAPNPAPAQA SLLAPASSAS QALATPLAPM AAPQTAILAP SPAPPLAPLP VLAPSPGAAP VLASSQTPVP VMAPSSTPGT SLASASPVPA PTPVLAPSST QTMLPAPVPS PLPSPASTQT LALAPALAPT LGGSSPSQTL SLGTGNPQGP FPTQTLSLTP ASSLVPTPAQ TLSLAPGPPL GPTQTLSLAP APPLAPASPV GPAPAHTLTL APASSSASLL APASVQTLTL SPAPVPTLGP AAAQTLALAP ASTQSPASQA SSLVVSASGA APLPVTMVSR LPVSKDEPDT LTLRSGPPSP PSTATSFGGP RPRRQPPPPP RSPFYLDSLE EKRKRQRSER LERIFQLSEA HGALAPVYGT EVLDFCTLPQ PVASPIGPRS PGPSHPTFWT YTEAAHRAVL FPQQRLDQLS EIIERFIFVM PPVEAPPPSL HACHPPPWLA PRQAAFQEQL ASELWPRARP LHRIVCNMRT QFPDLRLIQY DCGKLQTLAV LLRQLKAEGH RVLIFTQMTR MLDVLEQFLT YHGHLYLRLD GSTRVEQRQA LMERFNADKR IFCFILSTRS GGVGVNLTGA DTVVFYDSDW NPTMDAQAQD RCHRIGQTRD VHIYRLISER TVEENILKKA NQKRMLGDMA IEGGNFTTAY FKQQTIRELF DMPLEEPSSS SVPSAPEEEE ETVASKQTHI LEQALCRAED EEDIRAATQA KAEQVAELAE FNENDGFPAG EGEEAGRPGA EDEEMSRAEQ EIAALVEQLT PIERYAMKFL EASLEEVSRE ELKQAEEQVE AARKDLDQAK EEVFRLPQEE EEGPGAGDES SCGTGGGTHR RSKKAKAPER PGTRVSERLR GARAETQGAN HTPVISAHQT RSTTTPPRCS PARERVPRPA PRPRPTPASA PAAIPALVPV PVSAPVPISA PNPITILPVH ILPSPPPPSQ IPPCSSPACT PPPACTPPPA HTPPPAQTCL VTPSSPLLLG PPSVPISASV TNLPLGLRPE AELCAQALAS PESLELASVA SSETSSLSLV PPKDLLPVAV EILPVSEKNL SLTPSAPSLT LEAGSIPNGQ EQEAPDSAEG TTLTVLPEGE ELPLCVSESN GLELPPSAAS DEPLQEPLEA DRTSEELTEA KTPTSSPEKP QELVTAEVAA PSTSSSATSS PEGPSPARPP RRRTSADVEI RGQGTGRPGQ PPGPKVLRKL PGRLVTVVEE KELVRRRRQQ RGAASTLVPG VSETSASPGS PSVRSMSGPE SSPPIGGPCE AAPSSSLPTP PQQPFIARRH IELGVTGGGS PENGDGALLA ITPPAVKRRR GRPPKKNRSP ADAGRGVDEA PSSTLKGKTN GADPVPGPET LIVADPVLEP QLIPGPQPLG PQPVHRPNPL LSPVEKRRRG RPPKARDLPI PGTISSAGDG NSESRTQPPP HPSPLTPLPP LLVCPTATVA NTVTTVTIST SPPKRKRGRP PKNPPSPRPS QLPVLDRDST SVLESCGLGR RRQPQGQGES EGSSSDEDGS RPLTRLARLR LEAEGMRGRK SGGSMVVAVI QDDLDLADSG PGGLELTPPV VSLTPKLRST RLRPGSLVPP LETEKLPRKR AGAPVGGSPG LAKRGRLQPP SPLGPEGSVE ESEAEASGEE EEGDGTPRRR PGPRRLVGTT NQGDQRILRS SAPPSLAGPA VSHRGRKAKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with SRCAP?

The strongest Open Targets associations for SRCAP are Floating-Harbor syndrome, neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities, genetic disorder, Neurodevelopmental disorder and neurodegenerative disease.

How long is the SRCAP protein?

The Homo sapiens SRCAP protein (UniProt Q6ZRS2) is 3230 amino acids long.

Browse: Targets: S · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6ZRS2 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6ZRS2 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.