Protein FAM83H (FAM83H)
Homo sapiens — UniProt Q6ZRV2
Data last refreshed: (UniProt release unknown)
Key facts
Protein FAM83H (FAM83H) is a protein from Homo sapiens identified by UniProt accession Q6ZRV2, 1179 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q6ZRV2; gene symbol FAM83H.
- Organism: Homo sapiens.
- Length: 1179 amino acids.
- Top disease associations (Open Targets): amelogenesis imperfecta, type 3A, Hypocalcified amelogenesis imperfecta and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein FAM83H |
|---|---|
| UniProt accession | Q6ZRV2 |
| Gene | FAM83H |
| Organism | Homo sapiens |
| Length | 1179 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- amelogenesis imperfecta, type 3A · score 0.72
- Hypocalcified amelogenesis imperfecta · score 0.62
- neurodegenerative disease · score 0.45
- genetic disorder · score 0.19
- lean body mass · score 0.15
- fat body mass · score 0.11
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.09
- gallbladder carcinoma · score 0.08
- body weight · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZRV2-F1 | alphafold | PREDICTED | 49.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZRV2.
Amino-acid sequence (1179 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM83H?
The strongest Open Targets associations for FAM83H are amelogenesis imperfecta, type 3A, Hypocalcified amelogenesis imperfecta, neurodegenerative disease, genetic disorder and lean body mass.
How long is the FAM83H protein?
The Homo sapiens FAM83H protein (UniProt Q6ZRV2) is 1179 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZRV2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZRV2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.