Neurobeachin-like protein 1 (NBEAL1)

Homo sapiens — UniProt Q6ZS30

Gene: NBEAL1Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Neurobeachin-like protein 1 (NBEAL1) is a protein from Homo sapiens identified by UniProt accession Q6ZS30, 2694 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

UniProt accession: Q6ZS30; gene symbol NBEAL1.
Organism: Homo sapiens.
Length: 2694 amino acids.
Top disease associations (Open Targets): pulse pressure measurement, neurodegenerative disease and systolic blood pressure.
3D structure: AlphaFold model available.

Target properties

Protein name	Neurobeachin-like protein 1
UniProt accession	Q6ZS30
Gene	NBEAL1
Organism	Homo sapiens
Length	2694 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

pulse pressure measurement · score 0.33
neurodegenerative disease · score 0.31
systolic blood pressure · score 0.27
hematocrit · score 0.26
mean reticulocyte volume · score 0.21
coronary artery disease · score 0.16
coronary artery bypass · score 0.16
adolescent idiopathic scoliosis · score 0.16
coronary atherosclerosis · score 0.16
body mass index · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZS30-F1	alphafold	PREDICTED	74.83	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZS30.

Amino-acid sequence (2694 residues)

MASRERLFEL WMLYCTKKDP DYLKLWLDTF VSSYEQFLDV DFEKLPTRVD DMPPGISLLP DNILQVLRIQ LLQCVQKMAD GLEEQQQALS ILLVKFFIIL CRNLSNVEEI GTCSYINYVI TMTTLYIQQL KSKKKEKEMA DQTCIEEFVI HALAFCESLY DPYRNWRHRI SGRILSTVEK SRQKYKPASL TVEFVPFFYQ CFQESEHLKE SLKCCLLHLF GAIVAGGQRN ALQAISPATM EVLMRVLADC DSWEDGDPEE VGRKAELTLK CLTEVVHILL SSNSDQRQVE TSTILENYFK LLNSDHSALP NQRRSRQWEN RFIALQIKML NTITAMLDCT DRPVLQAIFL NSNCFEHLIR LLQNCKVFQG QLDCLAISTI QALTAVMNKS PAAKEVFKER IGYTHMLEVL KSLGQPPLEL LKELMNMAVE GDHTSVGILG ISNVQPLLLL IQWLPELQSH DLQIFISDWL KRICCINRQS RTTCVNANMG IRIIETLDLH SSLHQTCAEN LIAIHGSLGS QSVSSEEIRR LLRLLRVDES ESVHPYVTPV TRAILTMARK LSLESALQYF NLSHSMAGIS VPPIQKWPGS AFSFSAWFCL DQDQLTLGIA NKGGKRKQLY SFFTGSGMGF EAFITHSGML VVAVCTKREY ATVMLPDHSF CDSLWHNITV VHMPGKRPFG QSFVYIYDNG QQKVSAPLRF PAMNEPFTSC CIGSAGQRTT TPPPSQIPDP PFSSPITPHR TSFGGILSSA SWGGTIEKSK LITKLISAGT QDSEWGCPTS LEGQLGSVII FYEPLQPPQV KALYLAGPNC LSPWKCQESD MADLPGNILL YYTAKACKNS ICLDLSTNCL HGRLTGNKVV NWDIKDIINC IGGLNVLFPL LEQISHFSEG QIPEEKNEST VPESVTPVEG DWLVWTSTKA SESRLERNLV ATFILIVKHF IQRHPINQGN LIHSHGVATL GALLQKVPST LMDVNVLMAV QLLIEQVSLE KNMQLLQQMY QYLLFDFRIW NRGDFPFRIG HIQYLSTIIK DSRRVFRKKY GVQFLLDTLR IYYGNGCKYN ELSLDDIRTI RTSLYGLIKY FLCKGGSHEE IQSIMGYIAA TNEEEQLFGI LDVLFSLLRT SPTRGQLFLL LFEPGNADIL YALLLNQKYS DRLREIIFKI MEQMLKCTNV YERSKQHIRL REVGYSGLGL LLNEALVNTS LIKNLTHQII NTDPVINFKD LLSVVYISHR AHINVRVAIC RKVLQILQFQ PDAAHQISQQ VGWQDTLVRL FLKAKFENGN TLHKHSRAVL MKDNDKNMST EDTKKNSDEK TDEEKITSFA SANVSSDQWS LEDRHSLDSN TPLFPEDSSV GELSFKSENQ EEFWHSNPSH LSLDLSGIDS CEMSDSGSQV PDSLPSTPSP VESTKSFSVH SDRESSITND MGFSDDFSLL ESQERCEEEL LQLLTHILNY VMCKGLEKSD DDTWIERGQV FSALSKPGIS SELLRPSDEI KLTLLQKMLE WAISENREAK TNPVTAENAF RLVLIIQDFL QSEGLVNSNM WTEKLLEDMM LLFDCLSVCY SESPVWVKLS QIQIQLLLGF IGRGNLQVCA MASAKLNTLL QTKVIENQDE ACYILGKLEH VLSQSIKEQT EIYSFLIPLV RTLVSKIYEL LFMNLHLPSL PFTNGSSSFF EDFQEYCNSN EWQVYIEKYI VPYMKQYEAH TFYDGHENMA LYWKDCYEAL MVNMHKRDRE GGESKLKFQE LFVEPFNRKA RQENLRYNNM LKQLSSQQLA TLRRWKAIQL YLTCERGPWA KRKQNPIHWK LANVENYSRM RLKLVPNYNF KTHEEASALR DNLGIQHSQP SSDTLLLEVV KQVKVSDMVE DKLDLPEEDI TARVNVDEKE EQDQKEKLVL MEDCELITII DVIPGRLEIT TQHIYFYDGS IEKEDGVGFD FKWPHSQIRE IHLRRYNLRR SALEIFHVDQ SNYFLNFKKE VRNKIYSRLL SLHSPNSYYG SRSPQELFKA SGLTQKWVNR EISNFDYLIQ INTMAGRTYN DLAQYPVFPW ILQDYTSEEL DLNNPAVFRD LSKPIGVVNE KNAKAMREKY ENFEDPMGTI DKFHYGTHYS NSAGVMHYLI RVEPFTTLHI QLQSGRFDCA DRQFHSIPAT WQALMDNPYD VKELIPEFFY FPEFLENQNQ FNLGRLQISK ELVNDVILPK WAKSAEDFIY KHRKALESEY VSAHLHEWID LIFGYKQRGP AAVEALNVFY YCSYEGAVDL DALTDEKERK ALEGMINNFG QTPCQLLKEP HPPRLSAEEA VQKPTKIDTS TLNLFQHLPE LKSFFIEGIS DGIPLLKATI PKNQYRSFMS QGSPELLITI SMNYVIGTHG WLPYDRNISN YFTFIKDQTV TNPKTQRSIN GSFAPGLEIT SKLFVVSHDA KLLFSAGYWD NSIQVMSLTK GKIISHIIRH MDIVTCLATD YCGIHLISGS RDTTCMIWQI TQQGGVPVGL ASKPFQILYG HTNEVLSVGI STELDMAVSG SRDGTVIIHT IQKGQYMRTL RPPCESSLFL TIPNLAISWE GHIVVYSSTE EKTTLKDKNA LHLFSINGKY LGSQILKEQV SDICIIGEHI VTGSIQGFLS IRDLHSLNLS INPLAMRLPI HCVCVTKEYS HILVGLEDGK LIVVGVGKPA EMRSGQLSRK FWGSSKRLSQ ISAGETEYNT QDSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with NBEAL1?

The strongest Open Targets associations for NBEAL1 are pulse pressure measurement, neurodegenerative disease, systolic blood pressure, hematocrit and mean reticulocyte volume.

How long is the NBEAL1 protein?

The Homo sapiens NBEAL1 protein (UniProt Q6ZS30) is 2694 amino acids long.

Browse: Targets: N · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6ZS30 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6ZS30 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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