WD repeat- and FYVE domain-containing protein 4 (WDFY4)
Homo sapiens — UniProt Q6ZS81
Data last refreshed: (UniProt release unknown)
Key facts
WD repeat- and FYVE domain-containing protein 4 (WDFY4) is a protein from Homo sapiens identified by UniProt accession Q6ZS81, 3184 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q6ZS81; gene symbol WDFY4.
- Organism: Homo sapiens.
- Length: 3184 amino acids.
- Top disease associations (Open Targets): systemic lupus erythematosus, rheumatoid arthritis and primary biliary cirrhosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WD repeat- and FYVE domain-containing protein 4 |
|---|---|
| UniProt accession | Q6ZS81 |
| Gene | WDFY4 |
| Organism | Homo sapiens |
| Length | 3184 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.45
- rheumatoid arthritis · score 0.33
- primary biliary cirrhosis · score 0.30
- clinically amyopathic dermatomyositis · score 0.22
- adolescent idiopathic scoliosis · score 0.19
- Blackfan-Diamond anemia · score 0.09
- lung adenocarcinoma · score 0.07
- primary familial polycythemia due to EPO receptor mutation · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZS81-F2 | alphafold | PREDICTED | 82.23 | — |
| AF-Q6ZS81-F3 | alphafold | PREDICTED | 81.21 | — |
| AF-Q6ZS81-F1 | alphafold | PREDICTED | 81.04 | — |
| AF-Q6ZS81-F4 | alphafold | PREDICTED | 78.99 | — |
| AF-Q6ZS81-F5 | alphafold | PREDICTED | 78.05 | — |
| AF-Q6ZS81-F6 | alphafold | PREDICTED | 77.07 | — |
| AF-Q6ZS81-F8 | alphafold | PREDICTED | 76.96 | — |
| AF-Q6ZS81-F9 | alphafold | PREDICTED | 75.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZS81.
Amino-acid sequence (3184 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDFY4?
The strongest Open Targets associations for WDFY4 are systemic lupus erythematosus, rheumatoid arthritis, primary biliary cirrhosis, clinically amyopathic dermatomyositis and adolescent idiopathic scoliosis.
How long is the WDFY4 protein?
The Homo sapiens WDFY4 protein (UniProt Q6ZS81) is 3184 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZS81 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZS81 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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