E3 ubiquitin-protein ligase ARK2C (ARK2C)
Homo sapiens — UniProt Q6ZSG1
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase ARK2C (ARK2C) is a protein from Homo sapiens identified by UniProt accession Q6ZSG1, 346 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q6ZSG1; gene symbol ARK2C.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, reticulocyte count and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase ARK2C |
|---|---|
| UniProt accession | Q6ZSG1 |
| Gene | ARK2C |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.40
- reticulocyte count · score 0.22
- mean corpuscular volume · score 0.21
- mean reticulocyte volume · score 0.19
- mean corpuscular hemoglobin concentration · score 0.15
- mean corpuscular hemoglobin · score 0.13
- drug use measurement · score 0.13
- monocyte count · score 0.08
- platelet component distribution width · score 0.06
- neutrophil count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZSG1-F1 | alphafold | PREDICTED | 56.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZSG1.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARK2C?
The strongest Open Targets associations for ARK2C are Red cell distribution width, reticulocyte count, mean corpuscular volume, mean reticulocyte volume and mean corpuscular hemoglobin concentration.
How long is the ARK2C protein?
The Homo sapiens ARK2C protein (UniProt Q6ZSG1) is 346 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZSG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZSG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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