Inhibitory synaptic factor 2A (INSYN2A)
Homo sapiens — UniProt Q6ZSG2
Data last refreshed: (UniProt release unknown)
Key facts
Inhibitory synaptic factor 2A (INSYN2A) is a protein from Homo sapiens identified by UniProt accession Q6ZSG2, 479 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q6ZSG2; gene symbol INSYN2A.
- Organism: Homo sapiens.
- Length: 479 amino acids.
- Top disease associations (Open Targets): blood protein measurement, metabolite measurement and insulin resistance.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inhibitory synaptic factor 2A |
|---|---|
| UniProt accession | Q6ZSG2 |
| Gene | INSYN2A |
| Organism | Homo sapiens |
| Length | 479 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.26
- metabolite measurement · score 0.17
- insulin resistance · score 0.13
- longitudinal BMI measurement · score 0.11
- protein measurement · score 0.11
- high density lipoprotein cholesterol measurement · score 0.08
- sebaceous of Jadassohn nevus · score 0.04
- squamous cell carcinoma · score 0.04
- breast carcinoma · score 0.03
- mean corpuscular volume · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZSG2-F1 | alphafold | PREDICTED | 54.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZSG2.
Amino-acid sequence (479 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INSYN2A?
The strongest Open Targets associations for INSYN2A are blood protein measurement, metabolite measurement, insulin resistance, longitudinal BMI measurement and protein measurement.
How long is the INSYN2A protein?
The Homo sapiens INSYN2A protein (UniProt Q6ZSG2) is 479 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZSG2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZSG2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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