Calpain-12 (CAPN12)
Homo sapiens — UniProt Q6ZSI9
Data last refreshed: (UniProt release unknown)
Key facts
Calpain-12 (CAPN12) is a protein from Homo sapiens identified by UniProt accession Q6ZSI9, 719 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q6ZSI9; gene symbol CAPN12.
- Organism: Homo sapiens.
- Length: 719 amino acids.
- Top disease associations (Open Targets): platelet count, platelet crit and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calpain-12 |
|---|---|
| UniProt accession | Q6ZSI9 |
| Gene | CAPN12 |
| Organism | Homo sapiens |
| Length | 719 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- platelet count · score 0.35
- platelet crit · score 0.21
- mean platelet volume · score 0.17
- platelet component distribution width · score 0.15
- creatinine measurement · score 0.14
- diet measurement · score 0.14
- blood protein measurement · score 0.12
- reticulocyte measurement · score 0.08
- heart rate · score 0.06
- neuroimaging measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZSI9-F1 | alphafold | PREDICTED | 86.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZSI9.
Amino-acid sequence (719 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CAPN12?
The strongest Open Targets associations for CAPN12 are platelet count, platelet crit, mean platelet volume, platelet component distribution width and creatinine measurement.
How long is the CAPN12 protein?
The Homo sapiens CAPN12 protein (UniProt Q6ZSI9) is 719 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZSI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZSI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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