Protein shisa-6 (SHISA6)
Homo sapiens — UniProt Q6ZSJ9
Data last refreshed: (UniProt release unknown)
Key facts
Protein shisa-6 (SHISA6) is a protein from Homo sapiens identified by UniProt accession Q6ZSJ9, 500 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q6ZSJ9; gene symbol SHISA6.
- Organism: Homo sapiens.
- Length: 500 amino acids.
- Top disease associations (Open Targets): sleep duration, refractive error and risk-taking behaviour.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein shisa-6 |
|---|---|
| UniProt accession | Q6ZSJ9 |
| Gene | SHISA6 |
| Organism | Homo sapiens |
| Length | 500 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- sleep duration · score 0.44
- refractive error · score 0.31
- risk-taking behaviour · score 0.30
- Myopia · score 0.30
- neurodegenerative disease · score 0.28
- PHF-tau measurement · score 0.27
- musculoskeletal system disease · score 0.27
- refractive error measurement · score 0.26
- age at onset · score 0.26
- Abnormality of refraction · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZSJ9-F1 | alphafold | PREDICTED | 55.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZSJ9.
Amino-acid sequence (500 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHISA6?
The strongest Open Targets associations for SHISA6 are sleep duration, refractive error, risk-taking behaviour, Myopia and neurodegenerative disease.
How long is the SHISA6 protein?
The Homo sapiens SHISA6 protein (UniProt Q6ZSJ9) is 500 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZSJ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZSJ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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