Rho guanine nucleotide exchange factor 18 (ARHGEF18)
Homo sapiens — UniProt Q6ZSZ5
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 18 (ARHGEF18) is a protein from Homo sapiens identified by UniProt accession Q6ZSZ5, 1361 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q6ZSZ5; gene symbol ARHGEF18.
- Organism: Homo sapiens.
- Length: 1361 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, FEV/FVC ratio and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 18 |
|---|---|
| UniProt accession | Q6ZSZ5 |
| Gene | ARHGEF18 |
| Organism | Homo sapiens |
| Length | 1361 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.64
- FEV/FVC ratio · score 0.38
- lymphocyte count · score 0.37
- eosinophil count · score 0.37
- lymphocyte percentage of leukocytes · score 0.34
- basophil count · score 0.31
- neutrophil percentage of leukocytes · score 0.29
- eosinophil percentage of leukocytes · score 0.29
- cystatin C measurement · score 0.27
- hypertension · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZSZ5-F1 | alphafold | PREDICTED | 60.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZSZ5.
Amino-acid sequence (1361 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF18?
The strongest Open Targets associations for ARHGEF18 are retinitis pigmentosa, FEV/FVC ratio, lymphocyte count, eosinophil count and lymphocyte percentage of leukocytes.
How long is the ARHGEF18 protein?
The Homo sapiens ARHGEF18 protein (UniProt Q6ZSZ5) is 1361 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZSZ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZSZ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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