E3 ubiquitin-protein ligase UBR3 (UBR3)

Homo sapiens — UniProt Q6ZT12

Gene: UBR3Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

E3 ubiquitin-protein ligase UBR3 (UBR3) is a protein from Homo sapiens identified by UniProt accession Q6ZT12, 1888 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

UniProt accession: Q6ZT12; gene symbol UBR3.
Organism: Homo sapiens.
Length: 1888 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, platelet count and PHF-tau measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	E3 ubiquitin-protein ligase UBR3
UniProt accession	Q6ZT12
Gene	UBR3
Organism	Homo sapiens
Length	1888 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
platelet count · score 0.35
PHF-tau measurement · score 0.27
vital capacity · score 0.17
forced expiratory volume · score 0.16
grip strength measurement · score 0.14
diet measurement · score 0.09
obesity due to melanocortin 4 receptor deficiency · score 0.04
hypogonadotropic hypogonadism · score 0.03
lumbar disc degeneration · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZT12-F1	alphafold	PREDICTED	77.22	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZT12.

Amino-acid sequence (1888 residues)

MAAAAAAAVG GQQPSQPELP APGLALDKAA TAAHLKAALS RPDNRAGAEE LQALLERVLS AERPLAAAAG GEDAAAAGGG GGPGAAEEEA LEWCKCLLAG GGGYDEFCAA VRAYDPAALC GLVWTANFVA YRCRTCGISP CMSLCAECFH QGDHTGHDFN MFRSQAGGAC DCGDSNVMRE SGFCKRHQIK SSSNIPCVPK DLLMMSEFVL PRFIFCLIQY LREGYNEPAA DGPSEKDLNK VLQLLEPQIS FLEDLTKMGG AMRSVLTQVL TNQQNYKDLT SGLGENACVK KSHEKYLIAL KSSGLTYPED KLVYGVQEPS AGTSSLAVQG FIGATGTLGQ VDSSDEDDQD GSQGLGKRKR VKLSSGTKDQ SIMDVLKHKS FLEELLFWTI KYEFPQKMVT FLLNMLPDQE YKVAFTKTFV QHYAFIMKTL KKSHESDTMS NRIVHISVQL FSNEELARQV TEECQLLDIM VTVLLYMMES CLIKSELQDE ENSLHVVVNC GEALLKNNTY WPLVSDFINI LSHQSVAKRF LEDHGLLVTW MNFVSFFQGM NLNKRELNEH VEFESQTYYA AFAAELEACA QPMWGLLSHC KVRETQEYTR NVVRYCLEAL QDWFDAINFV DEPAPNQVTF HLPLHRYYAM FLSKAVKCQE LDLDSVLPDQ EMLMKLMIHP LQIQASLAEI HSNMWVRNGL QIKGQAMTYV QSHFCNSMID PDIYLLQVCA SRLDPDYFIS SVFERFKVVD LLTMASQHQN TVLDAEHERS MLEGALTFLV ILLSLRLHLG MSDDEILRAE MVAQLCMNDR THSSLLDLIP ENPNPKSGII PGSYSFESVL SAVADFKAPV FEPGGSMQQG MYTPKAEVWD QEFDPVMVIL RTVYRRDVQS AMDRYTAFLK QSGKFPGNPW PPYKKRTSLH PSYKGLMRLL HCKTLHIVLF TLLYKILMDH QNLSEHVLCM VLYLIELGLE NSAEEESDEE ASVGGPERCH DSWFPGSNLV SNMRHFINYV RVRVPETAPE VKRDSPASTS SDNLGSLQNS GTAQVFSLVA ERRKKFQEII NRSSSEANQV VRPKTSSKWS APGSAPQLTT AILEIKESIL SLLIKLHHKL SGKQNSYYPP WLDDIEILIQ PEIPKYSHGD GITAVERILL KAASQSRMNK RIIEEICRKV TPPVPPKKVT AAEKKTLDKE ERRQKARERQ QKLLAEFASR QKSFMETAMD VDSPENDIPM EITTAEPQVS EAVYDCVICG QSGPSSEDRP TGLVVLLQAS SVLGQCRDNV EPKKLPISEE EQIYPWDTCA AVHDVRLSLL QRYFKDSSCL LAVSIGWEGG VYVQTCGHTL HIDCHKSYME SLRNDQVLQG FSVDKGEFTC PLCRQFANSV LPCYPGSNVE NNPWQRPSNK SIQDLIKEVE ELQGRPGAFP SETNLSKEME SVMKDIKNTT QKKYRDYSKT PGSPDNDFLF MYSVARTNLE LELIHRGGNL CSGGASTAGK RSCLNQLFHV LALHMRLYSI DSEYNPWRKL TQLEEMNPQL GYEEQQPEVP ILYHDVTSLL LIQILMMPQP LRKDHFTCIV KVLFTLLYTQ ALAALSVKCS EEDRSAWKHA GALKKSTCDA EKSYEVLLSF VISELFKGKL YHEEGTQECA MVNPIAWSPE SMEKCLQDFC LPFLRITSLL QHHLFGEDLP SCQEEEEFSV LASCLGLLPT FYQTEHPFIS ASCLDWPVPA FDIITQWCFE IKSFTERHAE QGKALLIQES KWKLPHLLQL PENYNTIFQY YHRKTCSVCT KVPKDPAVCL VCGTFVCLKG LCCKQQSYCE CVLHSQNCGA GTGIFLLINA SVIIIIRGHR FCLWGSVYLD AHGEEDRDLR RGKPLYICKE RYKVLEQQWI SHTFDHINKR WGPHYNGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with UBR3?

The strongest Open Targets associations for UBR3 are neurodegenerative disease, platelet count, PHF-tau measurement, vital capacity and forced expiratory volume.

How long is the UBR3 protein?

The Homo sapiens UBR3 protein (UniProt Q6ZT12) is 1888 amino acids long.

Browse: Targets: U · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6ZT12 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6ZT12 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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