Transmembrane protein with metallophosphoesterase domain (TMPPE)
Homo sapiens — UniProt Q6ZT21
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein with metallophosphoesterase domain (TMPPE) is a protein from Homo sapiens identified by UniProt accession Q6ZT21, 453 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q6ZT21; gene symbol TMPPE.
- Organism: Homo sapiens.
- Length: 453 amino acids.
- Top disease associations (Open Targets): mucopolysaccharidosis type 4B, GM1 gangliosidosis type 1 and GM1 gangliosidosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein with metallophosphoesterase domain |
|---|---|
| UniProt accession | Q6ZT21 |
| Gene | TMPPE |
| Organism | Homo sapiens |
| Length | 453 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- mucopolysaccharidosis type 4B · score 0.52
- GM1 gangliosidosis type 1 · score 0.51
- GM1 gangliosidosis · score 0.50
- GM1 gangliosidosis type 2 · score 0.41
- GM1 gangliosidosis type 3 · score 0.40
- aspartate aminotransferase measurement · score 0.28
- eosinophil count · score 0.13
- genetic disorder · score 0.12
- mucopolysaccharidosis type 4 · score 0.12
- atopic eczema · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZT21-F1 | alphafold | PREDICTED | 91.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZT21.
Amino-acid sequence (453 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMPPE?
The strongest Open Targets associations for TMPPE are mucopolysaccharidosis type 4B, GM1 gangliosidosis type 1, GM1 gangliosidosis, GM1 gangliosidosis type 2 and GM1 gangliosidosis type 3.
How long is the TMPPE protein?
The Homo sapiens TMPPE protein (UniProt Q6ZT21) is 453 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZT21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZT21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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