Cilia- and flagella-associated protein 47 (CFAP47)

Homo sapiens — UniProt Q6ZTR5

Gene: CFAP47Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Cilia- and flagella-associated protein 47 (CFAP47) is a protein from Homo sapiens identified by UniProt accession Q6ZTR5, 3187 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

UniProt accession: Q6ZTR5; gene symbol CFAP47.
Organism: Homo sapiens.
Length: 3187 amino acids.
Top disease associations (Open Targets): spermatogenic failure, X-linked, 3, Male infertility due to large-headed multiflagellar polyploid spermatozoa and genetic disorder.
3D structure: AlphaFold model available.

Target properties

Protein name	Cilia- and flagella-associated protein 47
UniProt accession	Q6ZTR5
Gene	CFAP47
Organism	Homo sapiens
Length	3187 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

spermatogenic failure, X-linked, 3 · score 0.63
Male infertility due to large-headed multiflagellar polyploid spermatozoa · score 0.37
genetic disorder · score 0.17
Abnormality of neuronal migration · score 0.11
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.10
chromosome 22q11.2 microduplication syndrome · score 0.07
spermatogenic failure 72 · score 0.07
spermatogenic failure 18 · score 0.07
spermatogenic failure 46 · score 0.07

3D Structure (10)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZTR5-F4	alphafold	PREDICTED	78.93	—
AF-Q6ZTR5-F1	alphafold	PREDICTED	78.26	—
AF-Q6ZTR5-F5	alphafold	PREDICTED	78.24	—
AF-Q6ZTR5-F10	alphafold	PREDICTED	77.62	—
AF-Q6ZTR5-F6	alphafold	PREDICTED	76.88	—
AF-Q6ZTR5-F9	alphafold	PREDICTED	76.87	—
AF-Q6ZTR5-F7	alphafold	PREDICTED	76.22	—
AF-Q6ZTR5-F8	alphafold	PREDICTED	74.92	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZTR5.

Amino-acid sequence (3187 residues)

MNTQKGSLTI NVHRGSLAMS IQRGSLVPRD MDSSGRDMQL RVIPAEVKFL DTMAGRVYRL PITVHNICRW NQKIRFKEPV KPQFKLMLTS LDKELASGLQ MTAMVEYHPD KDEDTFDRLL ISIENKTTEI PLIGLIPSCQ LEIESVVNFG TLVANSKVYS KEITITNHGK APGIFKAEYH GQLPILIFPT SGIVDAKSSM VIKVDFCADQ PRIVDEEAIV ILQGQPEMLL SIKAHVVEQI IELLSMSSDR RLECIHFGPV FFGSSKIKHA RVYNNSPEPI NWVAIIQDDA VGEELGTDIQ QRTDIALNNL TYIRKIKNID TTIIISCLPN EGTLQPYQKT VITFCFTPKL MAVGKKDIGP SYRQDYALFL RFESVGSKDG FLRDDDYKTI KSERFQKVEL ALTGTGLPVL LQFDPGPVLN FKPCFMGERS EIQCIIKNQC ELLPVTYHFK KTANFEIDPE KGKITGGGMV DVMCSFVPHQ LGVFKVKQMI EIIGLVAEED LQSLSVKSFH HVYLAFNSIC KASTKKVVMK FDPGILPSIR NPTGKFVVKD LAKRKNYAPV AMLQSAMTRT HNHRSCEEPV KDMLLAFPND RAATIRSKDH HKHFRPIFTK VPRFNYVNHD FAYTTFEKQQ KKLHENYYAM YLKYLRSVRL QKKQAERERM YSYDDTDIGL EPGSGLKSPS LSEAEIEEEL SSAANSIRAN RLLTTRGIAS QEEESVRRKV LKGLKSEPST PQEKHDCSLM LTPKQIHQVI VGPSVLNFGN ICVNSPNTHL LHVINMLPMH VLLQLDTDLE ELQKTNQFSY VILPTSSTYI SMVFDSPTIG KFWKSFTFTV NNVPSGHILV VAVVQPVTLE LSSNELVLRP RGFFMKTCFR GTVRLYNRQN CCAQFQWQPV NTGRGIAFSI CPAKGTVEAY SSLECEVTWQ QGFSSPEEGE FILHVFQGNA LKLKCVAHLG RTKVLLLQPR ILFSNCPQGL TTWRKAILQN VGQNHAYFKV CSQSLLPIIN IIPSQGIVPF GGITVLNISC KPTVAEKFDT RAKVSIRHAN VIDLRIGGSA EIADVEINPD VFNFSGAYIG GTQIIPFVIK NKGITRARVE FNLKDFPDFS MDLKDKSEEF KDPAVPYIYS LELEENTSLE CSITFSPKEV TVVEFIIQVQ INFFESSKLY TKYLSSSPSN PKTVPLIRPC YVQATALQSP LNLSSTKFVF EIPLHEMNPN NKVTKTQNLV LYNITKHHVT WTLDLSNTGK LFKDGTFKFS VLNGILRPNE KYNVSISFCP NRPGTYTADI PMLLNYIPVC YKILHLTGEV KSPELLFDPP FIFFTPVPLD ITTVMDINIL PQNYFRNSTL CVQIPTVRLL DGEEIHPLSV KFPKGRVIPG SHSGINNKLT CHLSFKSSKP VSFFTNLLFC DDRKNWFSLP VTATAENCIL TIYPYMAIHL DKQNIILKND KDEYLKKTRD GVLPPYQDAK PPSPASIKKT YTTSKFNDAE PAKGNLFIGV EVLPENLHLD ESETSEEDHG SLEKEKYEQF LSLEEGTKAH YFFEKVVNAA QTWFSLFGWP EGPHSFSIPE TIRRDVYKMQ FYSSTSPPQK FSRQNDFSKY NKTIYDVLLH LSGKMPPGIN SSQSLPVDNH EKRVIQLHLQ HSSLLDFLNA QGGCISHVLP EFLLEPEDYK RWIEIMSSTN TMPVSSCTPK KKCSIVIEMS KFEAWSKRAW TDVFLQIYKV LVLSRVVPYC SNNMPPICVQ NTPKVNPCFA SSNIYSDSER ILLSWMNINY ENTRHVIWKN CHKDVIPSER WIVNFDKDLS DGLVFATQLG AYCPFLIESH FINMYTRPKS PEEYLHNCLI IVNTLYEIDF DVEIQATDIC DPNPILMLML CVYMYERLPT YLPKKVVSFE CTLHDTVLNK ILLKNSSSRN LVYNARIVGR DAADFSLSQK GNVVTISPRN EINVTLKFTS RFIRPAEASL LLISKPKNAV RGITMTFALK GKVLDFKAID IIKCESPCYQ FQEVTVNVKN PFHTAGDFSV ILVESSTFVS SPTKLTESRQ YPKHDDDMSS SGSDTDQGCS DSPNVLHTSI KSTFIREFFC SMHTVHLGVK GTSSLELRFL PFNMHVRYCV IILSNKKIGQ LIYVAEGKGM TPLPSSCLPM NTSSSPVYYS TTREEGPNKK YPVLYLKCKP YQILYVDLKL PMTNEAKEKA LAFAAQQQMS SIEYERRLIT GTLESSSIRV AIALLGLTKI ETLMLFRISK LRKPKTVSYT TEVSLPKYFY IPEKISIPWI PEPQVIKLSK AKASDGSVPL PLQFLPLQSG RYPCKILLKS RYDVRAYYVE GIVNEEQPEA KFEFETPAFE ALTQNIPIKN QTNDKWTFQV TIEGEWFYGP VDLHVGPDEI VEYPLTFKPI FECVITGKLI LQNEVDGREH IFDIKGVGKK PSALEHITVE CQVGNVTQKH ITLPHFTNTA LTFKVTADLP IVWGNPQITV YPYKEILYLI HVRPWKRGIL KGTITFSTTR RCTTRRKHDD YEEDTDQDQA LSCLDSITEQ SSILDDADTY GNFNNLRFWY NLEIHSTPGP PIEIMEMTCI ALDSTCIEIP LSNPKDRGLH LEVQLTSAAL NGDNEIILSP LQCTKYIVWY SPATTGYSDE SIIFQPEMAE EFWYLLKLTI ELPKPTTMPE IQCDLGKHVT QIIPLVNCTH ETLKLQVTNS NPENFVLDIN RKSQLIISPH STTELPVLFY PSALGRADHQ ACINFYCTQF TEWKFYLSGV GLFPQPLDTE RITTRIGLQS TIVIPFKNPT MEDVLIDIIL TSVEHPRNLV MDHCWDSFIY ESSAFRFSSP SEIQGIALPP KGNIDISLLF IPQIMKLHKT MVIIEMTKAN GKYWPIDNFD ELDIKFKSIV GIDSEEIQAI HWIYPIVGLP QAPPPKSPPV VIQCQSRKRA EEKVEIILNA GFFGFSLTPD LTEVLVIPKR NSHNFCEDPN EIPKIHEFEY EIQFESEAMK SKLESCVALY MIEKSYDIMA KRITFIFNLV FTPKKPLRSH ITLKIECVTE GIWKFPIMLI ATEPDTDAVI DIEGVGLFKE SVFELRLKSQ TRNPEPFTAH FLPGSDLEFF VKPQAGELLP FNTNGTLITV GFKPKMYCRK YKATLVIQTE EMYWKYEING LTPTTVPPKN AKAKIDATHK THDNMPVRPH NFVRENTKLI RTGVSSTIKG APLVKNQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with CFAP47?

The strongest Open Targets associations for CFAP47 are spermatogenic failure, X-linked, 3, Male infertility due to large-headed multiflagellar polyploid spermatozoa, genetic disorder, Abnormality of neuronal migration and azoospermia.

How long is the CFAP47 protein?

The Homo sapiens CFAP47 protein (UniProt Q6ZTR5) is 3187 amino acids long.

Browse: Targets: C · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6ZTR5 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6ZTR5 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.