Tubulin polyglutamylase complex subunit 1 (TPGS1)
Homo sapiens — UniProt Q6ZTW0
Data last refreshed: (UniProt release unknown)
Key facts
Tubulin polyglutamylase complex subunit 1 (TPGS1) is a protein from Homo sapiens identified by UniProt accession Q6ZTW0, 290 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q6ZTW0; gene symbol TPGS1.
- Organism: Homo sapiens.
- Length: 290 amino acids.
- Top disease associations (Open Targets): mean reticulocyte volume, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tubulin polyglutamylase complex subunit 1 |
|---|---|
| UniProt accession | Q6ZTW0 |
| Gene | TPGS1 |
| Organism | Homo sapiens |
| Length | 290 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- mean reticulocyte volume · score 0.15
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.06
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 20 · score 0.06
- spermatogenic failure 27 · score 0.06
- spermatogenic failure 18 · score 0.06
- spermatogenic failure 46 · score 0.06
- spermatogenic failure 65 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZTW0-F1 | alphafold | PREDICTED | 80.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZTW0.
Amino-acid sequence (290 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TPGS1?
The strongest Open Targets associations for TPGS1 are mean reticulocyte volume, azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion and spermatogenic failure 72.
How long is the TPGS1 protein?
The Homo sapiens TPGS1 protein (UniProt Q6ZTW0) is 290 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZTW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZTW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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