Capping protein-inhibiting regulator of actin dynamics (CRACD)
Homo sapiens — UniProt Q6ZU35
Data last refreshed: (UniProt release unknown)
Key facts
Capping protein-inhibiting regulator of actin dynamics (CRACD) is a protein from Homo sapiens identified by UniProt accession Q6ZU35, 1233 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q6ZU35; gene symbol CRACD.
- Organism: Homo sapiens.
- Length: 1233 amino acids.
- Top disease associations (Open Targets): body height, optic cup area measurement and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Capping protein-inhibiting regulator of actin dynamics |
|---|---|
| UniProt accession | Q6ZU35 |
| Gene | CRACD |
| Organism | Homo sapiens |
| Length | 1233 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- body height · score 0.33
- optic cup area measurement · score 0.30
- PHF-tau measurement · score 0.28
- attention deficit hyperactivity disorder · score 0.09
- schizophrenia 15 · score 0.09
- attention deficit-hyperactivity disorder 8 · score 0.09
- non-small cell lung carcinoma · score 0.07
- Tourette syndrome · score 0.07
- Phelan-McDermid syndrome · score 0.06
- Barrett's esophagus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZU35-F1 | alphafold | PREDICTED | 54.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZU35.
Amino-acid sequence (1233 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CRACD?
The strongest Open Targets associations for CRACD are body height, optic cup area measurement, PHF-tau measurement, attention deficit hyperactivity disorder and schizophrenia 15.
How long is the CRACD protein?
The Homo sapiens CRACD protein (UniProt Q6ZU35) is 1233 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZU35 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZU35 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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