Ubinuclein-2 (UBN2)
Homo sapiens — UniProt Q6ZU65
Data last refreshed: (UniProt release unknown)
Key facts
Ubinuclein-2 (UBN2) is a protein from Homo sapiens identified by UniProt accession Q6ZU65, 1347 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q6ZU65; gene symbol UBN2.
- Organism: Homo sapiens.
- Length: 1347 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, autism spectrum disorder and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubinuclein-2 |
|---|---|
| UniProt accession | Q6ZU65 |
| Gene | UBN2 |
| Organism | Homo sapiens |
| Length | 1347 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- autism spectrum disorder · score 0.27
- body mass index · score 0.07
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- hemoglobin D disease · score 0.05
- delta-beta-thalassemia · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- alpha-thalassemia-myelodysplastic syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZU65-F1 | alphafold | PREDICTED | 51.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZU65.
Amino-acid sequence (1347 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBN2?
The strongest Open Targets associations for UBN2 are neurodegenerative disease, autism spectrum disorder, body mass index, hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and hemoglobin D disease.
How long is the UBN2 protein?
The Homo sapiens UBN2 protein (UniProt Q6ZU65) is 1347 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZU65 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZU65 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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