Centrosomal protein 128 (CEP128)
Homo sapiens — UniProt Q6ZU80
Data last refreshed: (UniProt release unknown)
Key facts
Centrosomal protein 128 (CEP128) is a protein from Homo sapiens identified by UniProt accession Q6ZU80, 1094 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: Q6ZU80; gene symbol CEP128.
- Organism: Homo sapiens.
- Length: 1094 amino acids.
- Top disease associations (Open Targets): familial hyperthyroidism due to mutations in TSH receptor, hypothyroidism due to TSH receptor mutations and epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centrosomal protein 128 |
|---|---|
| UniProt accession | Q6ZU80 |
| Gene | CEP128 |
| Organism | Homo sapiens |
| Length | 1094 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- familial hyperthyroidism due to mutations in TSH receptor · score 0.40
- hypothyroidism due to TSH receptor mutations · score 0.39
- epilepsy · score 0.33
- developmental disability · score 0.33
- intellectual disability with language impairment · score 0.33
- radiation-induced brain injury · score 0.27
- response to radiation · score 0.27
- hypothyroidism · score 0.27
- influenza A (H1N1) · score 0.24
- Graves disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZU80-F1 | alphafold | PREDICTED | 74.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZU80.
Amino-acid sequence (1094 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEP128?
The strongest Open Targets associations for CEP128 are familial hyperthyroidism due to mutations in TSH receptor, hypothyroidism due to TSH receptor mutations, epilepsy, developmental disability and intellectual disability with language impairment.
How long is the CEP128 protein?
The Homo sapiens CEP128 protein (UniProt Q6ZU80) is 1094 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZU80 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZU80 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.